The Role of Smad3 in the Realization of the Growth Potential of Different Types of Neural Progenitor Cells and the Secretory Function of Neuroglia.

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-02 DOI:10.47056/0365-9615-2024-177-1-42-46

G. N. Zyuz'kov, L. Miroshnichenko, T. Polyakova, E. Simanina, A. Chaikovsky, V. Agafonov, L. A. Stavrova, E. V. Udut, A. A. Churin, V. Zhdanov

引用次数: 0

Abstract

The features of the participation of Smad3 in the functioning of neural stem cells (NSC), neuronal committed precursors (NCP), and neuroglial elements were studied in vitro. It was found that this intracellular signaling molecule enhances the clonogenic and proliferative activities of NCP and inhibits specialization of neuronal precursors. At the same time, Smad3 does not participate in the realization of the growth potential of NSC. With regard to the secretory function (production of neurotrophic growth factors) of neuroglial cells, the stimulating role of Smad3-mediated signaling was shown. These results indicate the promise of studying the possibility of using Smad3 as a fundamentally new target for neuroregenerative agents.

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Smad3 在实现不同类型神经祖细胞的生长潜能和神经胶质细胞分泌功能中的作用

研究人员在体外研究了Smad3参与神经干细胞（NSC）、神经元前体（NCP）和神经胶质细胞功能的特点。研究发现，这种细胞内信号分子能增强神经元前体的克隆和增殖活性，抑制神经元前体的特化。同时，Smad3 并不参与实现 NSC 的生长潜能。在神经胶质细胞的分泌功能（产生神经营养生长因子）方面，Smad3 介导的信号传导起到了刺激作用。这些结果表明，有望研究将 Smad3 作为神经再生药物的新靶点的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.