Effect of Modified Forms of Sodium Humate PowHumus on the Balance of Arginine in Peritoneal Macrophages of Intact Mice.

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-02 DOI:10.47056/0365-9615-2024-177-1-80-85

E. S. Trofimova, M. Zykova, M. G. Danilets, A. A. Ligacheva, E. Sherstoboev, N. S. Selivanova, L. A. Azarkina, A. Zhirkova, Yu. Zhang, I. V. Perminova, V. Zhdanov, M. Belousov

引用次数: 0

Abstract

Substances of silver nanoparticles dialyzed through a 13 kDa membrane, synthesized in a medium of humic ligands modified with hydroquinone and 2-hydroxynaphthoquinone from PowHumus brown coal, specifically enhance the M2 properties of peritoneal macrophages due to inhibition of NO synthase and significant activation of arginase, thus enhancing anti-inflammatory properties of cells. In small, but effective concentrations, they do not have cytotoxic properties and do not contain pyrogenic impurities. The studied humates are able to influence the mechanisms of immune response formation and are an effective means for correcting inflammation and regeneration.

查看原文本刊更多论文

改良型腐植酸钠对完整小鼠腹膜巨噬细胞精氨酸平衡的影响

通过 13 kDa 膜透析的银纳米粒子物质是在用对苯二酚和来自 PowHumus 褐煤的 2-hydroxynaphthoquinone 改性的腐殖质配体介质中合成的，由于抑制了 NO 合酶并显著激活了精氨酸酶，它们能特异性地增强腹腔巨噬细胞的 M2 特性，从而增强细胞的抗炎特性。腐殖酸盐的浓度虽小，但效果显著，它们不具有细胞毒性，也不含致热杂质。所研究的腐殖酸盐能够影响免疫反应的形成机制，是纠正炎症和再生的有效手段。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.