Quaternization of Methyl Picolinate with Some Phenacyl Bromides. Synthesis of DL-Baikiain Alkaloid

Abstract

By fusing methyl picolinate with phenacyl bromides, the corresponding phenacyl salts were obtained, cyclization of which in acetic anhydride led to previously undescribed 3-aryl-1H-pyrido[2,1-c][1,4]oxazinium bromides. Reduction of the quaternary salts of methyl picolinate followed by acid hydrolysis leads to the alkaloid DL-baikiain.