National system for microbiological monitoring of microorganisms resistant to antimicrobial drugs

Abstract

Antimicrobial resistance in pathogens is a global problem associated with millions of additional deaths per year. In addition to the risks to human, animal and environmental health, this phenomenon undermines the functioning of agri-food systems. Rospotrebnadzor is doing its best to counteract the spread of antibiotic resistance in Russia, both through medical organizations and through food products. The Central Research Institute of Epidemiology of Rospotrebnadzor has established the heterogeneity of populations of ESKAPE pathogens. t has been shown that even within the same line, pathogenic isolates can have their own distinctive features formed during the process of evolution. The clonal similarity of strains isolated from food, as well as the circulation in the food chain of transmissible genes KPC, NDM, MBLBS, which cause multidrug resistance in bacteria, pose a threat to public health. For timely and adequate diagnosis, carrying out epidemiological surveillance and preventing the widespread spread of antimicrobial resistance, the institute’s specialists are developing sets of reagents that allow prompt detect single genes associated with resistance directly in biological material. Currently, domestic scientists are working on creating a system for monitoring resistant strains and genetic determinants of resistance (genomic epidemiological surveillance).