The Hypothesis and Research on the Regulation of Mouse Feeding Behavior by Astrocytes in the Lateral Hypothalamic Area

Zefu Yin, Yuzhe Jiang, Jie Chen
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Abstract

Numerous studies have shown that the central nervous system plays a crucial role in regulating feeding behavior [1]. Within the central nervous system, many nuclei and neural circuitry are involved in regulating feeding behavior, such as the ventral tegmental area (VTA), lateral hypothalamus (LH), tuberomammillary nucleus (TN), and amygdala (CeA). Among these, the lateral hypothalamus is a critical target for the regulation of homeostatic feeding. Previous studies on LH regulation of feeding behavior have mostly focused on neurons and neural circuits, with relatively fewer studies on astrocytes.
下丘脑外侧区星形胶质细胞调控小鼠摄食行为的假说与研究
大量研究表明,中枢神经系统在调节摄食行为中起着至关重要的作用[1]。在中枢神经系统中,许多核团和神经回路都参与了摄食行为的调控,如腹侧被盖区(VTA)、外侧下丘脑(LH)、结节乳头核(TN)和杏仁核(CeA)。其中,外侧下丘脑是调节摄食平衡的关键靶点。以往对 LH 调节摄食行为的研究大多集中在神经元和神经回路上,对星形胶质细胞的研究相对较少。
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