Calotropis Gigantea Latex-Derived Zinc Oxide Nanoparticles: Biosynthesis, Characterization, and Biofunctional Applications

Eng Pub Date : 2024-07-09 DOI:10.3390/eng5030073

Jayalekshmi C, Rajiv Periakaruppan, V. Romanovski, Karungan Selvaraj Vijai Selvaraj, Noura Al-Dayan

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Abstract

Latex of C. gigantea was used to synthesize zinc oxide nanoparticles (ZnO NPs) by the green chemistry approach. The crystalline size, shape, and purity of as-synthesized ZnO NPs were characterized through scanning electron microscopy with energy-dispersive X-ray spectroscopy, transmission electron microscopy, X-ray diffraction analysis, and Fourier-transform infrared spectroscopy techniques. Crystalline, spherical ZnO NPs with an average size of 21.8 nm were formed. In addition, the biological properties of the ZnO NPs, such as antioxidant and antibacterial activity, were evaluated by 2,2-diphenyl-1-picrylhydrazyl assay and the agar well-diffusion method. The highest free radical scavenging activities of 83.11 ± 1.89 % were observed at a concentration of 350 μg/mL of C. gigantea latex-mediated ZnO NPs. The latex in the C. gigantea latex-mediated ZnO NPs inhibited the growth of pathogenic bacteria. The maximum zone of inhibition was found in P. aeruginosa and S. aureus. C. gigantea latex-mediated ZnO NPs have significant biocompatibility and broad-spectrum antibacterial properties against wound-causing bacteria and, therefore, can be suggested for use in the formulation of novel creams or gels for healing applications.

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鹅掌楸胶乳衍生的纳米氧化锌颗粒：生物合成、表征和生物功能应用

采用绿色化学方法，利用千层塔的胶乳合成了氧化锌纳米粒子（ZnO NPs）。通过扫描电子显微镜与能量色散 X 射线光谱、透射电子显微镜、X 射线衍射分析和傅立叶变换红外光谱技术对合成的 ZnO NPs 的结晶尺寸、形状和纯度进行了表征。结果表明，所制备的 ZnO NPs 为结晶球形，平均尺寸为 21.8 nm。此外，还采用 2,2-二苯基-1-苦基肼测定法和琼脂井扩散法评估了 ZnO NPs 的生物特性，如抗氧化和抗菌活性。在浓度为 350 μg/mL 的千层塔乳胶介导的 ZnO NPs 中观察到最高的自由基清除活性（83.11 ± 1.89 %）。千层塔乳胶介导的 ZnO NPs 中的乳胶抑制了病原菌的生长。铜绿假单胞菌和金黄色葡萄球菌的抑制区最大。千层塔乳胶介导的氧化锌氮氧化物具有显著的生物相容性和广谱抗菌特性，可有效抑制伤口致病菌的生长，因此可建议用于配制新型膏剂或凝胶，用于伤口愈合。

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来源期刊

Eng

CiteScore

2.10

自引率

0.00%

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