Corrected QT interval and QT dispersion in temporal lobe epilepsy in children and adolescent

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-09 DOI:10.29333/ejgm/14787

Amr Hemeda Mustafa, Mahmoud Mohammed Mahmoud Saber, Hosny Abdel Kareem Ahmed Mahmoud, Mostafa Abd Elazeem Hassan Ahamed, Ahmed Hagag Ismail Ahmed, Mohammed Fawzy Fouad, Ahmed Mohammed Farid EL-Moazen, Abd El-Monem M Hassan, Ahmed Ibrahim Mostafa, Ahmed Abady Ahmed Ali, Ahmed Ali Faheem Abdo, Al-Hussein Mustafa Zahran, A. Almarghany, Moustafa Mohamed Eldeib, Abdelhamid Ismail Abdelhamid Abu Rahhal, Ahmed Saadeldeen Ibrahem Mansour, Ashraf Yahia Abdel Elgawad, Ali Elsayed Ali Elagamy, El Sayed Hamed Fahmy, Khalid A Rashed, Ehab Ibrahim Sorour

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Abstract

Aim: The purpose of this research was to contrast (heart-rate corrected QT interval) QTc, and (QT dispersion) QTd intervals in individuals with (temporal lobe epilepsy) TLE and those without TLE using a standard 12-lead electrocardiogram. Patients & methods: This cross-sectional research was undertaken on 100 cases aged 10 to 20 diagnosed with epilepsy in accordance with 2017 ILAE criteria. The patients’ informed written permission was acquired. In our study, we included 100 cases: 50 with TLE and 50 with non-TLE verified by seizure semiology. All patients were subjected to a comprehensive history, clinical examination (heart rate, pulse, and blood pressure), and clinical evaluation, which included a comprehensive epilepsy history. On the basis of neurology service documents or the initial publication of the international classification of diseases, 9th revision (ICD9) diagnostic or 10th revision (ICD10) codes for epilepsy, diagnostic age for epilepsy was calculated. Results: The mean QT interval in group I was 418.30±25.48 ms while that of group II was 406.20±27.63 ms, the mean QTc of group I was 513.60±61.94 ms and was 488.70±50.65 in group II. The calculated QTd was with a mean of 57.60±25.05 ms while that of group II was 43.60±31.89 ms. It means that the QT interval, QTc, and QTd values were considerably greater in the group I (temporal epilepsy) contrasted with group II (non-temporal epilepsy); (p=0.025, 0.030, and 0.016, respectively). The mean QT, QTc, and QTd values for FE were 409.20±20.80, 500.70±55.60, and 52.60±29.70 ms, respectively. QT, QTc, and QTd mean values for patients with widespread epilepsy were 412.00±25.60, 505.00±68.60, and 46.20±28.70 ms. QT, QTc, and QTd interval were insignificantly different between focal and generalized epilepsy. The longer an illness progresses, the longer the QT and QTc intervals, as there was a substantial positive correlation among illness’s course and QT interval (r=0.391, p<0.001) and QTc interval (r=0.289, p=0.011), but there was no noticeable impact on QTd due to the illness’s duration, as we found an insignificant correlation among duration of illness and QTC and QTd. Conclusions: Our findings indicate that; QTc interval and QTd are longer in epilepsy cases more among TLE cases contrasted with non-TLE. Since there was no distinction among different epilepsy types (focal and generalized).

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儿童和青少年颞叶癫痫的校正 QT 间期和 QT 离散度

目的：本研究旨在使用标准12导联心电图对比（颞叶癫痫）TLE患者和无TLE患者的（心率校正QT间期）QTc和（QT弥散）QTd间期：这项横断面研究根据2017年ILAE标准，对100例10至20岁的癫痫患者进行了诊断。研究获得了患者的知情书面许可。在我们的研究中，我们纳入了 100 个病例：其中50例为TLE患者，50例为通过癫痫发作半身像验证的非TLE患者。所有患者均接受了全面的病史、临床检查（心率、脉搏和血压）和临床评估，其中包括全面的癫痫病史。根据神经内科服务文件或最初公布的国际疾病分类第 9 次修订版（ICD9）癫痫诊断代码或第 10 次修订版（ICD10）癫痫代码，计算癫痫诊断年龄：第一组的平均 QT 间期为（418.30±25.48）毫秒，第二组为（406.20±27.63）毫秒；第一组的平均 QTc 为（513.60±61.94）毫秒，第二组为（488.70±50.65）毫秒。计算得出的 QTd 平均值为（57.60±25.05）毫秒，而 II 组为（43.60±31.89）毫秒。这意味着第一组（颞叶癫痫）的 QT 间期、QTc 和 QTd 值比第二组（非颞叶癫痫）要大得多；（P 分别为 0.025、0.030 和 0.016）。FE 的平均 QT、QTc 和 QTd 值分别为 409.20±20.80、500.70±55.60 和 52.60±29.70 ms。广泛性癫痫患者的 QT、QTc 和 QTd 平均值分别为 412.00±25.60、505.00±68.60 和 46.20±28.70 ms。局灶性癫痫和广泛性癫痫患者的 QT、QTc 和 QTd 间期差异不明显。病程越长，QT 和 QTc 间期越长，因为病程与 QT 间期（r=0.391，p<0.001）和 QTc 间期（r=0.289，p=0.011）呈显著正相关，但病程对 QTd 没有明显影响，因为我们发现病程与 QTC 和 QTd 的相关性不显著：我们的研究结果表明：与非 TLE 患者相比，TLE 患者的 QTc 间期和 QTd 更长。由于不同癫痫类型（局灶性和全身性）之间没有区别，我们的研究结果表明，TLE 和非 TLE 患者的 QTc 间期和 QTd 更长。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.