Treatment Related Factors Associated with Non-adherence to Anti-Tuberculosis Treatment

Delta Medical College Journal Pub Date : 2024-07-14 DOI:10.3329/dmcj.v9i2.74873

Md Motahar Hossain, M. Flora, Md Saydur Rahman, Md Nurul Amin, Murshida Mosharref, F. Zafreen

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Abstract

Background: Non-adherence to anti-tuberculosis treatment may result in persistent infectiousness on the part of the patient and a higher rate of treatment failure, relapse and drug resistance and therefore, is a significant barrier to the success in tuberculosis control. Objective: To determine the treatment related factors associated with non-adherence to anti-tuberculosis treatment among tuberculosis patients. Materials and method: This case control study was carried out among purposively selected 47tuberculosis patients non-adherent to treatment (cases) and 94 tuberculosis patients adherent to treatment (controls) and were interviewed with a semi-structured questionnaire and checklist in selected DOTS centres of Dhaka city. Results: Statistical analysis shows that, factors like delay in seeking tuberculosis treatment for >6 weeks (OR=4.57; 95% CI, 1.48-14.1) and getting medicine weekly once (OR=2.8; 95% CI, 1.13-6.77) were more likely to be associated with non-adherence to treatment. Lessfrequent visit by health providers (p=0.02), no support for side effect (p=0.042) and non-observation of medication (p=0.009) were also found significant. The reasons behind missing anti-TB doses among non-adherent cases were due to feeling better (53.2%), personal reason (25.5%), feeling worse (19.1%) and forgot to take medicine (2.2%). Conclusion: Mass awareness among the tuberculosis patients is required to improve attitude towards anti-tuberculosis treatment and activities of tuberculosis control programme require further strengthening especially in targeting the patients of low economic status. Delta Med Col J. Jan 2021;9(2): 96-100

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与不坚持抗结核治疗有关的治疗相关因素

背景：不坚持抗结核治疗可能会导致患者持续感染，提高治疗失败率、复发率和耐药率，因此是成功控制结核病的重要障碍：确定与肺结核患者不坚持抗结核治疗有关的治疗相关因素。材料和方法：这项病例对照研究在达卡市选定的短期直接观察治疗中心有目的性地选择了 47 名不坚持治疗的肺结核患者（病例）和 94 名坚持治疗的肺结核患者（对照组），并通过半结构化问卷和核对表对他们进行了访谈：统计分析表明，结核病治疗延迟超过 6 周（OR=4.57；95% CI，1.48-14.1）和每周服药一次（OR=2.8；95% CI，1.13-6.77）等因素更有可能与不坚持治疗有关。医疗服务提供者很少来访（P=0.02）、副作用得不到支持（P=0.042）和不观察用药情况（P=0.009）也与不坚持治疗有显著关系。在未坚持服药的病例中，漏服抗结核药物的原因包括感觉好些了（53.2%）、个人原因（25.5%）、感觉更糟（19.1%）和忘记服药（2.2%）：结论：需要提高结核病患者的大众意识，以改善他们对抗结核治疗的态度，同时需要进一步加强结核病控制计划的活动，尤其是针对经济状况较差的患者：96-100

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Delta Medical College Journal

自引率

0.00%

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审稿时长

20 weeks