Oxidative stress-mediated epigenetic remodeling, metastatic progression and cell signaling in cancer

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-15 DOI:10.1515/oncologie-2024-0157

A. Phull, Sadia Qamar Arain, Abdul Majid, Humaira Fatima, Madiha Ahmed, Song-Ja Kim

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引用次数: 0

Abstract

Cancer is a serious public health issue and cases are rising at a high rate around the world. Altered production of reactive oxygen species (ROS) causes oxidative stress (OS) which plays a vital role in cancer development by disrupting signaling pathways and genomic integrity in the cellular microenvironment. In this study, we reviewed the regulation of noncoding RNAs, histone modifications, and DNA methylation which OS is involved in. These mechanisms promote cancer growth, metastasis, and resistance to chemotherapeutic agents. There is significant potential to improve patient outcomes through the development of customized medications and interventions that precisely address the role of OS in the onset and progression of cancer. Redox-modulating drugs, antioxidant-based therapies, and measures to restore regular cellular activity and OS-modulated signaling pathways are some examples of these strategies. One other hypothesis rationalizes the cancer-suppressing effect of OS, which acts as a two-edged condition that warns against the use of antioxidants for cancer treatment and management. The present study was executed to review the impact of OS on epigenetic machinery, the evolution of metastatic cancer, and how OS mediates cellular signaling. Along with, insights into the potential of targeting OS-mediated mechanisms for cancer therapy.

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癌症中氧化应激介导的表观遗传重塑、转移进展和细胞信号传导

癌症是一个严重的公共卫生问题，全世界的癌症病例都在高速上升。活性氧（ROS）产生的变化会导致氧化应激（OS），而氧化应激会破坏细胞微环境中的信号通路和基因组完整性，从而在癌症发展过程中扮演重要角色。在本研究中，我们回顾了 OS 所涉及的非编码 RNA、组蛋白修饰和 DNA 甲基化的调控。这些机制促进了癌症的生长、转移和对化疗药物的耐药性。通过开发定制药物和干预措施，精确解决操作系统在癌症发生和发展中的作用，在改善患者预后方面大有可为。氧化还原调节药物、抗氧化疗法以及恢复正常细胞活动和OS调节信号通路的措施就是这些策略的一些例子。还有一种假说认为操作系统具有抑制癌症的作用，它是一把双刃剑，警告人们不要使用抗氧化剂来治疗和控制癌症。本研究旨在回顾 OS 对表观遗传机制的影响、转移性癌症的演变以及 OS 如何介导细胞信号传导。此外，本研究还深入探讨了针对操作系统介导的癌症治疗机制的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.