Advances in multiparametric magnetic resonance imaging combined with biomarkers for the diagnosis of high-grade prostate cancer

IF 1.6 4区医学 Q2 SURGERY

Frontiers in Surgery Pub Date : 2024-07-16 DOI:10.3389/fsurg.2024.1429831

Song-lin Li, Ming-yong Zha, Qi Wang, Yong Tang

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引用次数: 0

Abstract

Clinical decisions based on the test results for prostate-specific antigen often result in overdiagnosis and overtreatment. Multiparametric magnetic resonance imaging (mpMRI) can be used to identify high-grade prostate cancer (HGPCa; Gleason score ≥3 + 4); however, certain limitations remain such as inter-reader variability and false negatives. The combination of mpMRI and prostate cancer (PCa) biomarkers (prostate-specific antigen density, Proclarix, TMPRSS2:ERG gene fusion, Michigan prostate score, ExoDX prostate intelliscore, four kallikrein score, select molecular diagnosis, prostate health index, and prostate health index density) demonstrates high accuracy in the diagnosis of HGPCa, ensuring that patients avoid unnecessary prostate biopsies with a low leakage rate. This manuscript describes the characteristics and diagnostic performance of each biomarker alone and in combination with mpMRI, with the intension to provide a basis for decision-making in the diagnosis and treatment of HGPCa. Additionally, we explored the applicability of the combination protocol to the Asian population.

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多参数磁共振成像结合生物标记诊断高级别前列腺癌的进展

根据前列腺特异性抗原的检测结果做出临床决定往往会导致过度诊断和过度治疗。多参数磁共振成像（mpMRI）可用于鉴别高级别前列腺癌（HGPCa；格里森评分≥3 + 4），但仍存在某些局限性，如阅片人员之间的差异和假阴性。mpMRI与前列腺癌（PCa）生物标记物（前列腺特异性抗原密度、Prolclarix、TMPRSS2:ERG基因融合、密歇根前列腺评分、ExoDX前列腺智能评分、四项allikrein评分、选择性分子诊断、前列腺健康指数和前列腺健康指数密度）的结合显示了诊断HGPCa的高准确性，可确保患者避免不必要的前列腺活检，且漏检率低。本手稿介绍了每种生物标记物单独使用或与 mpMRI 结合使用的特点和诊断性能，旨在为 HGPCa 的诊断和治疗提供决策依据。此外，我们还探讨了组合方案在亚洲人群中的适用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Surgery Medicine-Surgery

CiteScore

1.90

自引率

11.10%

发文量

1872

审稿时长

12 weeks

期刊介绍： Evidence of surgical interventions go back to prehistoric times. Since then, the field of surgery has developed into a complex array of specialties and procedures, particularly with the advent of microsurgery, lasers and minimally invasive techniques. The advanced skills now required from surgeons has led to ever increasing specialization, though these still share important fundamental principles. Frontiers in Surgery is the umbrella journal representing the publication interests of all surgical specialties. It is divided into several “Specialty Sections” listed below. All these sections have their own Specialty Chief Editor, Editorial Board and homepage, but all articles carry the citation Frontiers in Surgery. Frontiers in Surgery calls upon medical professionals and scientists from all surgical specialties to publish their experimental and clinical studies in this journal. By assembling all surgical specialties, which nonetheless retain their independence, under the common umbrella of Frontiers in Surgery, a powerful publication venue is created. Since there is often overlap and common ground between the different surgical specialties, assembly of all surgical disciplines into a single journal will foster a collaborative dialogue amongst the surgical community. This means that publications, which are also of interest to other surgical specialties, will reach a wider audience and have greater impact. The aim of this multidisciplinary journal is to create a discussion and knowledge platform of advances and research findings in surgical practice today to continuously improve clinical management of patients and foster innovation in this field.