Neuropathic phenotypes of type 1 diabetes are related to different signatures of magnetic resonance spectroscopy-assessed brain metabolites

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2024-07-16 DOI:10.1016/j.clinph.2024.06.017

Tine M. Hansen , Suganthiya S. Croosu , Johan Røikjer , Carsten D. Mørch , Niels Ejskjaer , Jens B. Frøkjær

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引用次数: 0

Abstract

Objectives

The study aimed to investigate brain metabolites in type 1 diabetes and the associations with disease characteristics. We explored the metabolic profiles predicting different neuropathic phenotypes using multiple linear regression analyses.

Methods

We compared brain metabolites in 55 adults with type 1 diabetes (including painful diabetic peripheral neuropathy (DPN), painless DPN, without DPN) with 20 healthy controls. Proton magnetic resonance spectroscopy measurements (N-acetylaspartate (NAA), glutamate (glu), myo-inositol (mI), and glycerophosphocholine (GPC) were obtained in ratios to creatine (cre)) from the parietal region, anterior cingulate cortex and thalamus.

Results

The overall diabetes group revealed decreased parietal NAA/cre compared to healthy controls (1.41 ± 0.12 vs. 1.55 ± 0.13,p < 0.001) and increased mI/cre (parietal: 0.62 ± 0.08 vs. 0.57 ± 0.07,p = 0.025, cingulate: 0.65 ± 0.08 vs. 0.60 ± 0.08,p = 0.033). Reduced NAA/cre was associated with more severe DPN (all p ≤ 0.04) whereas increased mI/cre was associated with higher hemoglobin A_1c (HbA_1c) (p = 0.02). Diabetes was predicted from decreased parietal NAA/cre, increased parietal ml/cre, and decreased thalamic glu/cre. DPN was predicted from decreased parietal NAA/cre and increased GPC/cre. Painful DPN was predicted from increased parietal GPC/cre and thalamic glu/cre.

Conclusions

Specific metabolic brain profiles were linked to the different phenotypes of diabetes, DPN and painful DPN.

Significance

Assessment of metabolic profiles could be relevant for detailed understanding of central neuropathy in diabetes.

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1 型糖尿病的神经病理性表型与磁共振波谱评估的大脑代谢物的不同特征有关

研究旨在调查 1 型糖尿病患者的脑代谢物及其与疾病特征的关系。方法我们比较了 55 名 1 型糖尿病成人患者（包括疼痛型糖尿病周围神经病变（DPN）、无痛型糖尿病周围神经病变、无 DPN）和 20 名健康对照者的脑代谢物。质子磁共振光谱测量了顶叶区、前扣带回皮层和丘脑的N-乙酰天冬氨酸（NAA）、谷氨酸（glu）、肌醇（mI）和甘油磷酸胆碱（GPC）与肌酸（cre）的比率。结果与健康对照组相比，糖尿病组顶叶 NAA/cre 降低（1.41 ± 0.12 vs. 1.55 ± 0.13，p < 0.001），mI/cre 增加（顶叶：0.62 ± 0.08 vs. 0.57 ± 0.07，p = 0.025，扣带回：0.65 ± 0.08 vs. 0.57 ± 0.07，p = 0.025，丘脑：0.62 ± 0.08 vs. 0.57 ± 0.07，p = 0.025）：0.65 ± 0.08 vs. 0.60 ± 0.08,p = 0.033）。NAA/cre 减少与更严重的 DPN 相关（所有 p 均小于 0.04），而 mI/cre 增加与更高的血红蛋白 A1c（HbA1c）相关（p = 0.02）。顶叶 NAA/cre 减少、顶叶 ml/cre 增加和丘脑 glu/cre 减少均可预测糖尿病。顶叶 NAA/cre 减少和 GPC/cre 增加可预测 DPN。结论特定的脑代谢图谱与糖尿病、DPN 和疼痛性 DPN 的不同表型有关。意义评估代谢图谱有助于详细了解糖尿病中枢神经病变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.