Recent Advances in Nanotechnology‐Mediated Noninvasive Transdermal and Topical Delivery of Proteins

IF 11.1 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Small Science Pub Date : 2024-07-16 DOI:10.1002/smsc.202400175

Junghyeon Ko, Jeong‐Uk Kim, Subin Choi, Ye‐Sol Kim, Su‐Bin Park, Joo‐Young Kim, Hyeon‐Jin Kim, Young‐Sun Lee, Young‐Hyeon An, Nathaniel S. Hwang

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Abstract

Protein therapeutics are emerging as essential technologies due to their functional and chemical properties. However, their application is currently limited to delivery by oral and injection methods—the former being inefficient and the latter invasive and potentially tissue damaging. Researchers are, therefore, exploring noninvasive delivery systems for proteins through the skin, including transdermal and topical delivery. The large molecular size of proteins presents a key challenge for skin penetration, hindering their ability to penetrate the dense skin lamellar structure. This review focuses on using nanoparticles as carriers to increase protein stability and enhance skin penetration. The use of noninvasive or minimally invasive enhancers for controlling and improving penetration depth is also examined. Furthermore, the physical properties of nanoparticles that affect delivery are evaluated, aiming to propose ways to advance transdermal and topical delivery methods in the future.

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纳米技术介导的非侵入性经皮和局部输送蛋白质的最新进展

蛋白质疗法因其功能和化学特性而成为新兴的重要技术。然而，它们的应用目前仅限于口服和注射给药方法--前者效率低下，后者具有侵入性并可能对组织造成损害。因此，研究人员正在探索蛋白质通过皮肤的非侵入性给药系统，包括透皮给药和局部给药。蛋白质的大分子尺寸是皮肤穿透的一个关键挑战，阻碍了其穿透致密皮肤片层结构的能力。本综述将重点讨论如何利用纳米颗粒作为载体来提高蛋白质的稳定性并增强皮肤渗透性。此外，还探讨了如何使用非侵入性或微侵入性增强剂来控制和改善渗透深度。此外，还对影响给药的纳米颗粒的物理特性进行了评估，旨在提出未来推进透皮和局部给药方法的方法。

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来源期刊

Small Science

CiteScore

14.00

自引率

2.40%

发文量

期刊介绍： Small Science is a premium multidisciplinary open access journal dedicated to publishing impactful research from all areas of nanoscience and nanotechnology. It features interdisciplinary original research and focused review articles on relevant topics. The journal covers design, characterization, mechanism, technology, and application of micro-/nanoscale structures and systems in various fields including physics, chemistry, materials science, engineering, environmental science, life science, biology, and medicine. It welcomes innovative interdisciplinary research and its readership includes professionals from academia and industry in fields such as chemistry, physics, materials science, biology, engineering, and environmental and analytical science. Small Science is indexed and abstracted in CAS, DOAJ, Clarivate Analytics, ProQuest Central, Publicly Available Content Database, Science Database, SCOPUS, and Web of Science.