The influence of novelty detection on the 40-Hz auditory steady-state response in schizophrenia: A novel hypothesis from meta-analysis

IF 5.3 2区 医学 Q1 CLINICAL NEUROLOGY
Shunsuke Sugiyama , Koji Inui , Kazutaka Ohi , Toshiki Shioiri
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引用次数: 0

Abstract

The 40-Hz auditory steady-state response (ASSR) is influenced not only by parameters such as attention, stimulus type, and analysis level but also by stimulus duration and inter-stimulus interval (ISI). In this meta-analysis, we examined these parameters in 33 studies that investigated 40-Hz ASSRs in patients with schizophrenia. The average Hedges' g random effect sizes were − 0.47 and − 0.43 for spectral power and phase-locking, respectively. We also found differences in ASSR measures based on stimulus duration and ISI. In particular, ISI was shown to significantly influence differences in the 40-Hz ASSR between healthy controls and patients with schizophrenia. We proposed a novel hypothesis focusing on the role of novelty detection, dependent on stimulus duration and ISI, as a critical factor in determining these differences. Specifically, longer stimulus durations and shorter ISIs under random presentation, or shorter stimulus durations and longer ISIs under repetitive presentation, decrease the 40-Hz ASSR in healthy controls. Patients with schizophrenia show minimal changes in response to stimulus duration and ISI, thus reducing the difference between controls and patients. This hypothesis can consistently explain most of the studies that have failed to show a reduction in 40-Hz ASSR in patients with schizophrenia. Increased novelty-related activity, reflected as an increase in auditory evoked potential components at stimulus onset, such as the N1, could suppress the 40-Hz ASSR, potentially reducing the peak measures of spectral power and phase-locking. To establish the 40-Hz ASSR as a truly valuable biomarker for schizophrenia, further systematic research using paradigms with various stimulus durations and ISIs is needed.

新奇感检测对精神分裂症患者 40 赫兹听觉稳态反应的影响:来自荟萃分析的新假设
40 赫兹听觉稳态反应(ASSR)不仅受注意力、刺激类型和分析水平等参数的影响,还受刺激持续时间和刺激间期(ISI)的影响。在这项荟萃分析中,我们对 33 项调查精神分裂症患者 40Hz ASSR 的研究中的这些参数进行了分析。频谱功率和锁相的平均赫奇斯 g 随机效应大小分别为 - 0.47 和 - 0.43。我们还发现了基于刺激持续时间和 ISI 的 ASSR 测量差异。特别是,ISI 对健康对照组和精神分裂症患者之间 40Hz ASSR 的差异有显著影响。我们提出了一个新的假设,即新奇感检测是决定这些差异的关键因素,而新奇感检测则取决于刺激持续时间和 ISI。具体来说,在随机呈现的情况下,较长的刺激持续时间和较短的 ISI,或者在重复呈现的情况下,较短的刺激持续时间和较长的 ISI,都会降低健康对照组的 40-Hz ASSR。精神分裂症患者对刺激持续时间和 ISI 的反应变化极小,从而缩小了对照组和患者之间的差异。这一假说可以解释大多数未能显示精神分裂症患者 40-Hz ASSR 减少的研究。与新奇相关的活动增加,反映为刺激开始时听觉诱发电位成分(如 N1)的增加,可能会抑制 40-Hz ASSR,从而可能降低频谱功率和锁相的峰值测量。要将 40-Hz ASSR 确立为精神分裂症真正有价值的生物标志物,还需要使用不同刺激持续时间和 ISI 的范例进行进一步的系统研究。
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来源期刊
CiteScore
12.00
自引率
1.80%
发文量
153
审稿时长
56 days
期刊介绍: Progress in Neuro-Psychopharmacology & Biological Psychiatry is an international and multidisciplinary journal which aims to ensure the rapid publication of authoritative reviews and research papers dealing with experimental and clinical aspects of neuro-psychopharmacology and biological psychiatry. Issues of the journal are regularly devoted wholly in or in part to a topical subject. Progress in Neuro-Psychopharmacology & Biological Psychiatry does not publish work on the actions of biological extracts unless the pharmacological active molecular substrate and/or specific receptor binding properties of the extract compounds are elucidated.
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