Disruption of relapse to cocaine and morphine seeking by LiCl-induced aversive counterconditioning following memory retrieval

IF 5.3 2区 医学 Q1 CLINICAL NEUROLOGY
Qian Tang , Zhonghao Li , Fushen Zhang , Lei Han , Weidan Pu
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引用次数: 0

Abstract

Substance use disorder is conceptualized as a form of maladaptive learning, whereby drug-associated memories, elicited by the presence of stimuli related to drug contexts or cues, contribute to the persistent recurrence of craving and the reinstatement of drug-seeking behavior. Hence, use of pharmacology or non-pharmacology way to disrupt drug-related memory holds promise to prevent relapse. Several studies have shown that memories can be unstable and susceptible to modification during the retrieval reactivation phase, termed the “reconsolidation time window”. In this study, we use the classical conditioned place preference (CPP) model to investigate the role of aversive counterconditioning on drug-related memories during reconsolidation. Specifically, we uncovered that reconditioning drug cues through counterconditioning with LiCl-induced aversive outcomes following drug memory retrieval reduces subsequent drug-seeking behavior. Notably, the recall of cocaine- or morphine-CPP was eliminated when LiCl-induced aversive counterconditioning was performed 10 min, but not 6 h (outside the reconsolidation time window) after cocaine or morphine memory retrieval. In addition, the effect of LiCl-induced aversive counterconditioning could last for about 14 days. These results suggest that aversive counterconditioning during the reconsolidation of cocaine or morphine memory can prevent the re-seeking of cocaine or morphine, presumably by updating or replacing cocaine or morphine memories with aversive information.

记忆检索后,锂盐诱导的厌恶性反条件作用会干扰可卡因和吗啡寻求的复发
药物滥用障碍被认为是一种适应不良的学习形式,在这种学习形式中,与毒品相关的记忆会在出现与毒品相关的环境或线索的刺激时被激发出来,从而导致渴求的持续复发和寻求毒品行为的恢复。因此,利用药理学或非药理学方法破坏与毒品相关的记忆有望防止复吸。一些研究表明,在被称为 "再巩固时间窗 "的检索再激活阶段,记忆可能是不稳定的,并且容易被修改。在本研究中,我们使用经典条件性位置偏好(CPP)模型来研究厌恶性反条件在再巩固过程中对药物相关记忆的作用。具体来说,我们发现在毒品记忆检索后,通过氯化锂诱导的厌恶结果的反条件来重新调节毒品线索,可以减少随后的毒品寻求行为。值得注意的是,在可卡因或吗啡记忆检索后10分钟,而不是6小时(在重新巩固时间窗之外)进行锂盐诱导的厌恶性反调节,可卡因或吗啡-CPP的回忆就会消失。此外,锂盐诱导的厌恶性反调节作用可持续约14天。这些结果表明,在重新巩固可卡因或吗啡记忆期间进行厌恶性反调节,可以防止重新寻找可卡因或吗啡,这可能是通过用厌恶性信息更新或替换可卡因或吗啡记忆来实现的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
12.00
自引率
1.80%
发文量
153
审稿时长
56 days
期刊介绍: Progress in Neuro-Psychopharmacology & Biological Psychiatry is an international and multidisciplinary journal which aims to ensure the rapid publication of authoritative reviews and research papers dealing with experimental and clinical aspects of neuro-psychopharmacology and biological psychiatry. Issues of the journal are regularly devoted wholly in or in part to a topical subject. Progress in Neuro-Psychopharmacology & Biological Psychiatry does not publish work on the actions of biological extracts unless the pharmacological active molecular substrate and/or specific receptor binding properties of the extract compounds are elucidated.
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