Identifying relevant factors influencing cancer-related fatigue in patients with diffuse large B-cell lymphoma during chemotherapy

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-07-19 DOI:10.5498/wjp.v14.i7.1017

Xiu-Qiao Hao, Xiang-Dan Yang, Yue Qi

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Abstract

BACKGROUND Diffuse large B-cell lymphoma (DLBCL) is a rapidly growing malignant tumor, and chemotherapy is one of the treatments used to combat it. Although advancements of science and technology have resulted in more and more patients being able to receive effective treatment, they still face side effects such as fatigue and weakness. It is important to thoroughly investigate the factors that contribute to cancer-related fatigue (CRF) during chemotherapy. AIM To explore the factors related to CRF, anxiety, depression, and mindfulness levels in patients with DLBCL during chemotherapy. METHODS General information was collected from the electronic medical records of eligible patients. Sleep quality and mindfulness level scores in patients with DLBCL during chemotherapy were evaluated by the Pittsburgh Sleep Quality Index and Five Facet Mindfulness Questionnaire-Short Form. The Piper Fatigue Scale was used to evaluate the CRF status. The Self-Rating Anxiety Scale and Self-Rating Depression Scale were used to evaluate anxiety and depression status. Univariate analysis and multivariate regression analysis were used to investigate the factors related to CRF. RESULTS The overall average CRF level in 62 patients with DLBCL during chemotherapy was 5.74 ± 2.51. In 25 patients, the highest rate of mild fatigue was in the cognitive dimension (40.32%), and in 35 patients the highest moderate fatigue rate in the behavioral dimension (56.45%). In the emotional dimension, severe fatigue had the highest rate of occurrence, 34 cases or 29.03%. The CRF score was positively correlated with cancer experience (all P < 0.01) and negatively correlated with cancer treatment efficacy (all P < 0.01). Tumor staging, chemotherapy cycle, self-efficacy level, and anxiety and depression level were related to CRF in patients with DLBCL during chemotherapy. CONCLUSION There was a significant correlation between CRF and perceptual control level in patients. Tumor staging, chemotherapy cycle, self-efficacy level, and anxiety and depression level influenced CRF in patients with DLBCL during chemotherapy.

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确定影响弥漫大 B 细胞淋巴瘤患者化疗期间癌症相关疲劳的相关因素

背景弥漫性大 B 细胞淋巴瘤（DLBCL）是一种生长迅速的恶性肿瘤，化疗是治疗该病的方法之一。虽然科学技术的进步使越来越多的患者能够接受有效的治疗，但他们仍然面临着疲劳和虚弱等副作用。深入研究化疗期间导致癌症相关疲劳（CRF）的因素非常重要。目的探讨 DLBCL 患者化疗期间 CRF、焦虑、抑郁和正念水平的相关因素。方法从符合条件的患者的电子病历中收集一般信息。采用匹兹堡睡眠质量指数和五面正念问卷-简表评估化疗期间DLBCL患者的睡眠质量和正念水平得分。Piper 疲劳量表用于评估 CRF 状态。焦虑自评量表和抑郁自评量表用于评估焦虑和抑郁状况。采用单变量分析和多变量回归分析来研究与 CRF 相关的因素。结果 62例DLBCL患者在化疗期间的总体平均CRF水平为（5.74 ± 2.51）。在 25 名患者中，认知维度的轻度疲劳率最高（40.32%），在 35 名患者中，行为维度的中度疲劳率最高（56.45%）。在情绪方面，严重疲劳的发生率最高，有 34 例，占 29.03%。CRF 评分与癌症经历呈正相关（均为 P <0.01），与癌症治疗效果呈负相关（均为 P <0.01）。DLBCL 患者的肿瘤分期、化疗周期、自我效能水平以及化疗期间的焦虑和抑郁水平与 CRF 相关。结论患者的 CRF 与感知控制水平之间存在显著相关性。肿瘤分期、化疗周期、自我效能感水平以及焦虑和抑郁水平对化疗期间DLBCL患者的CRF有影响。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567