Prospective evaluation of nasal septal perforation repair with absorbable plate and temporalis fascia in early adolescent patients

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Emmanuel J. Jáuregui , Austin Zhu , Suhong Tong , Jeremy Prager , Christian R. Francom
{"title":"Prospective evaluation of nasal septal perforation repair with absorbable plate and temporalis fascia in early adolescent patients","authors":"Emmanuel J. Jáuregui ,&nbsp;Austin Zhu ,&nbsp;Suhong Tong ,&nbsp;Jeremy Prager ,&nbsp;Christian R. Francom","doi":"10.1016/j.ijporl.2024.112044","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><p>In the pediatric population, nasal septal perforations (NSP) are rare, and management is not well described. The use of various techniques has been reported in adults, including the use of interposition grafts, however this technique has not been described in the pediatric population.</p><p>Our hypothesis is that the closure rate using absorbable <span>d</span>-lactide and <span>l</span>-lactide (each 50 %), polymer (PDLLA) plates as interposition grafts with temporalis fascia for NSP repair in the pediatric population will be an effective method compared to previous techniques.</p></div><div><h3>Methods</h3><p>Chart review was performed on patients who underwent NSP repair before June 2021, results were compared to a prospective evaluation of an interposition plate graft for repair at a tertiary care children's hospital.</p></div><div><h3>Results</h3><p>Fifteen patients via previous techniques and 5 patients via PDLLA and fascia graft were reviewed. Etiology of perforations included 45 % idiopathic, 25 % traumatic, and 15 % iatrogenic. In the previous techniques group, 10 were male, mean (median) age 14.4 years (15.2). Average size of NSP was 12.6 mm ± 6.6 mm (SD). 14/15 (93 %) patients had resolution of symptoms at 10-week follow-up, and 2/15 (13 %) required repeat repair. Five prospective patients were repaired with a PDLLA and fascia interposition graft, 4 were female, mean (median) age 14.6 years (Nassif and Scott, 2021 Feb 1) [14]. Average size of NSP was 11 mm ± 2.2 mm (SD). 100 % had resolution of symptoms at 10-week follow-up, 0 needed repeat surgery. No significant difference was found in size of NSP or in need for repeat procedure (p &gt; 0.05) between the groups.</p></div><div><h3>Conclusion</h3><p>Use of absorbable PDLLA interposition grafts with temporalis fascia for NSP repair in the pediatric population is effective at closing and resolving symptoms associated with NSP.</p></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165587624001988","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

Objectives

In the pediatric population, nasal septal perforations (NSP) are rare, and management is not well described. The use of various techniques has been reported in adults, including the use of interposition grafts, however this technique has not been described in the pediatric population.

Our hypothesis is that the closure rate using absorbable d-lactide and l-lactide (each 50 %), polymer (PDLLA) plates as interposition grafts with temporalis fascia for NSP repair in the pediatric population will be an effective method compared to previous techniques.

Methods

Chart review was performed on patients who underwent NSP repair before June 2021, results were compared to a prospective evaluation of an interposition plate graft for repair at a tertiary care children's hospital.

Results

Fifteen patients via previous techniques and 5 patients via PDLLA and fascia graft were reviewed. Etiology of perforations included 45 % idiopathic, 25 % traumatic, and 15 % iatrogenic. In the previous techniques group, 10 were male, mean (median) age 14.4 years (15.2). Average size of NSP was 12.6 mm ± 6.6 mm (SD). 14/15 (93 %) patients had resolution of symptoms at 10-week follow-up, and 2/15 (13 %) required repeat repair. Five prospective patients were repaired with a PDLLA and fascia interposition graft, 4 were female, mean (median) age 14.6 years (Nassif and Scott, 2021 Feb 1) [14]. Average size of NSP was 11 mm ± 2.2 mm (SD). 100 % had resolution of symptoms at 10-week follow-up, 0 needed repeat surgery. No significant difference was found in size of NSP or in need for repeat procedure (p > 0.05) between the groups.

Conclusion

Use of absorbable PDLLA interposition grafts with temporalis fascia for NSP repair in the pediatric population is effective at closing and resolving symptoms associated with NSP.

使用可吸收钢板和颞筋膜对青少年患者鼻中隔穿孔进行修复的前瞻性评估
目的 在儿科人群中,鼻中隔穿孔(NSP)非常罕见,其治疗方法也没有很好的描述。我们的假设是,在儿科人群中使用可吸收的 d-内酰胺和 l-内酰胺(各占 50%)、聚合物(PDLLA)板作为颞筋膜间移植物进行鼻中隔穿孔修复的闭合率与之前的技术相比将是一种有效的方法。方法对 2021 年 6 月前接受 NSP 修复术的患者进行病历回顾,并将结果与一家三级儿童医院的穿插板移植修复术前瞻性评估结果进行比较。结果回顾了 15 例采用之前技术的患者和 5 例采用 PDLLA 和筋膜移植的患者。穿孔的病因包括 45% 的特发性穿孔、25% 的外伤性穿孔和 15% 的先天性穿孔。在之前采用的技术组中,10 人为男性,平均年龄(中位数)为 14.4 岁(15.2 岁)。NSP 的平均大小为 12.6 毫米 ± 6.6 毫米(标清)。14/15(93%)名患者在10周的随访中症状得到缓解,2/15(13%)名患者需要再次进行修复。5名前瞻性患者采用PDLLA和筋膜插植术进行了修复,其中4名为女性,平均(中位)年龄为14.6岁(Nassif和Scott,2021年2月1日)[14]。NSP的平均大小为11毫米±2.2毫米(标清)。100%的患者在10周的随访中症状得到缓解,0人需要再次手术。结论在儿科人群中使用可吸收的 PDLLA 与颞筋膜间移植物进行 NSP 修复,能有效关闭和解决 NSP 相关症状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信