Acylphloroglucinol derivatives from the aerial parts of Syzygium borneense and their cytotoxic activities

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2024-07-18 DOI:10.1016/j.phytol.2024.07.006

Thi Van Nguyen , Thi Quynh Do , Marc Litaudon , Thuy Linh Nguyen , Van Nam Vu , Thu Huong Tran , Thi Mai Huong Doan , Van Cuong Pham

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Abstract

Four new acylphloroglucinol derivatives, borneensinones A-D (1–4) along with five known compounds (5-9) were isolated from the aerial parts of Syzygium borneense. Their structures were elucidated based on the interpretation of spectrometric and spectroscopic data (HRESI-MS, 1D- and 2D-NMR) and by comparison with literature data for known compounds. All acylphloroglucinol derivatives (1–6) were tested for their cytotoxic activities against four human cancer cell lines (KB, MCF-7, HepG-2, and A549). Among the six tested compounds, compound 6 exhibited the strongest inhibitory activity against four tested cancer cell lines, with IC₅₀ values ranging from 6.21 to 26.96 μM. Compound 1 was more active against KB and HepG2 comparing to the A549 and MCF7 cells. Compound 5 had a moderate cytotoxicity with IC₅₀ values ranging from 27.71 to 97.32 μM.

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茜草气生部分中的酰基氯葡萄糖醇衍生物及其细胞毒性活性

研究人员从刺五加的气生部分分离出了四种新的酰基氯葡萄糖苷衍生物，即刺五加内酯 A-D（1-4）和五种已知化合物（5-9）。根据对光谱数据（HRESI-MS、1D-和 2D-NMR）的解释以及与已知化合物文献数据的比较，阐明了这些化合物的结构。测试了所有酰基氯代葡萄糖醇衍生物（1-6）对四种人类癌症细胞系（KB、MCF-7、HepG-2 和 A549）的细胞毒活性。在六个受测化合物中，化合物 6 对四种受测癌细胞株的抑制活性最强，IC50 值在 6.21 到 26.96 μM 之间。与 A549 和 MCF7 细胞相比，化合物 1 对 KB 和 HepG2 的活性更高。化合物 5 具有中等的细胞毒性，IC50 值在 27.71 到 97.32 μM 之间。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.