Use of antidepressants in the treatment of chronic orofacial pain caused by temporomandibular disorders: A randomized controlled clinical trial

Medicina clinica (English ed.) Pub Date : 2024-07-18 DOI:10.1016/j.medcle.2024.02.007

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Abstract

Background and objective

Temporomandibular disorders (TMDs) are a common pathology, associated with pain in the facial territory and with associated psychological disorders, such as anxiety and depression. The aim of this study was to evaluate the efficacy of antidepressants in the treatment of pain associated with TMD.

Materials and methods

Sixty four patients suffering from chronic orofacial pain, randomly distributed in 3 groups: control group treated with night splint, group treated with 10 mg/day of citalopram and group treated with 25 mg/day of amitriptyline. Pain intensity was assessed, randomly, by a single blinded evaluator, according to the VAS at baseline and after one, three, six and nine weeks.

Results

All groups showed a reduction of pain throughout the period of time evaluated, however, the group treated with amitriptyline showed the best pain reduction results 3.3 ± 1.5, 1.5 ± 1.4 and 0.9 ± 1.3 at 3, 6 and 9 weeks, respectively.

Conclusions

Low doses of amitriptyline appear to be a good therapeutic option in patients with TMDs suffering from chronic orofacial pain.

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使用抗抑郁药治疗由颞下颌关节紊乱引起的慢性口面部疼痛：随机对照临床试验

背景和目的颞下颌关节紊乱症（TMDs）是一种常见病，与面部疼痛以及焦虑和抑郁等相关心理障碍有关。本研究旨在评估抗抑郁药治疗 TMD 相关疼痛的疗效。材料和方法64 名慢性口面部疼痛患者随机分为三组：使用夜间夹板治疗的对照组、每天服用 10 毫克西酞普兰的治疗组和每天服用 25 毫克阿米替林的治疗组。在基线和一周、三周、六周和九周之后，由一名单盲评估员根据 VAS 随机评估疼痛强度。结果在整个评估期间，所有组的疼痛都有所减轻，但阿米替林治疗组的疼痛减轻效果最好，分别为 3.3 ± 1.5、1.3 ± 1.5、1.3 ± 1.5、1.3 ± 1.5、1.3 ± 1.5、1.3 ± 1.5、1.3 ± 1.5、1.3 ± 1.5、1.3 ± 1.5。结论小剂量阿米替林似乎是治疗患有慢性口面部疼痛的 TMD 患者的良好选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicina clinica (English ed.)

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