Incidence of acute liver failure and its associated mortality in patients with dengue infection: A systematic review and meta-analysis

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health Pub Date : 2024-07-14 DOI:10.1016/j.jiph.2024.102497

Wasit Wongtrakul , Kantnatt Charatcharoenwitthaya , Khemajira Karaketklang , Phunchai Charatcharoenwitthaya

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Abstract

Acute liver failure (ALF) is a devastating consequence of dengue infection. This systematic review and meta-analysis assessed the incidence of ALF in dengue infection and its associated mortality. We systematically searched the EMBASE and MEDLINE databases from inception to December 2023 for observational studies reporting ALF incidence and mortality in dengue patients. Twenty-one studies encompassing 26,839 dengue-infected patients were included. Meta-analysis revealed a pooled incidence of ALF in cases of general dengue infection of 2.0 % (95 % CI, 1.2–3.0 %), with 1.2 % (95 % CI, 0.6–2.1 %) in adults and 5.0 % (95 % CI, 1.5–10.2 %) in children. ALF incidence was 17.3 % (95 % CI, 6.5 %−31.5 %) in severe dengue and 7.4 % (95 % CI, 0.8–18.5 %) in dengue shock syndrome. The pooled mortality rate of dengue-associated ALF was 47.0 % (95 % CI, 32.9–61.2 %). These findings underscore the detrimental impact of dengue infection on the development of the relatively uncommon, albeit life-threatening, condition of ALF.

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登革热感染患者急性肝功能衰竭的发生率及其相关死亡率：系统回顾与荟萃分析

急性肝衰竭（ALF）是登革热感染的一种破坏性后果。本系统综述和荟萃分析评估了登革热感染中 ALF 的发病率及其相关死亡率。我们系统地检索了 EMBASE 和 MEDLINE 数据库中从开始到 2023 年 12 月报告登革热患者 ALF 发病率和死亡率的观察性研究。共纳入 21 项研究，涵盖 26,839 名登革热感染者。Meta 分析显示，在一般登革热感染病例中，ALF 的总发病率为 2.0 %（95 % CI，1.2-3.0 %），其中成人为 1.2 %（95 % CI，0.6-2.1 %），儿童为 5.0 %（95 % CI，1.5-10.2 %）。严重登革热的 ALF 发生率为 17.3%（95% CI，6.5%-31.5%），登革热休克综合征的 ALF 发生率为 7.4%（95% CI，0.8%-18.5%）。登革热相关 ALF 的总死亡率为 47.0%（95% CI，32.9-61.2%）。这些发现强调了登革热感染对 ALF 这种相对不常见但却危及生命的疾病的不利影响。

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来源期刊

Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES

CiteScore

13.10

自引率

1.50%

发文量

203

审稿时长

96 days

期刊介绍： The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.