Epidemiological and clinical characteristics of monkeypox among people with and without HIV in Peru: a national observational study

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health Pub Date : 2024-07-10 DOI:10.1016/j.jiph.2024.102494

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引用次数: 0

Abstract

Background

In Latin America, Peru has the second highest number of cases of monkeypox (Mpox), of which more than 50 % are Human Immunodeficiency Virus (HIV)-positive. Here, we compared the epidemiological and clinical characteristics of Mpox between people with and without HIV in Peru.

Methods

We conducted a national retrospective study using data on confirmed cases of Mpox reported by the Peruvian National Surveillance System from 15 June 2022 to 31 December 2023.

Results

A total of 3561 confirmed cases of Mpox were included. Of these, 2123 (60 %) patients were people living with HIV (PLWH), with increased odds for those aged 30 years or older, homosexual (adjusted odds ratio [aOR] 8.58 [6.95–10.59], p<0.0001), bisexual (aOR=4.44 [3.46–5.69], p<0.0001), sex workers (aOR=2.24 [1.07–4.68], p=0.032), people with a history of syphilis (aOR=2.07 [1.66–2.58], p<0.001), and hospitalized (aOR=3.08 [2.03–4.68], p<0.001). PLWH were more likely to have proctitis (aOR=1.73 [1.26–2.37], p=0.001). The overall mortality was 20 of 3561 (0.56 %). Among PLWH and Mpox, more deaths occurred in hospitalized (p<0.001) and non-ART (p<0.001) individuals.

Conclusion

Our findings highlight that HIV infection among Mpox cases in Peru is associated with high-risk sexual behaviour and a high likelihood of hospitalization.

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秘鲁艾滋病毒感染者和非艾滋病毒感染者中猴痘的流行病学和临床特征：一项全国性观察研究

背景在拉丁美洲，秘鲁的猴痘病例数量位居第二，其中50%以上为人类免疫缺陷病毒（HIV）阳性。在此，我们比较了秘鲁猴痘的流行病学特征和临床特征。方法我们利用秘鲁国家监测系统在2022年6月15日至2023年12月31日期间报告的猴痘确诊病例数据，开展了一项全国性的回顾性研究。结果共纳入3561例猴痘确诊病例。其中，2123 例（60%）患者为艾滋病毒感染者（PLWH），年龄在 30 岁或以上、同性恋（调整后的几率比 [aOR] 8.58 [6.95-10.59]，p<0.0001）、双性恋（aOR=4.44 [3.46-5.69]，p<0.0001）、性工作者（aOR=2.24 [1.07-4.68]，p=0.032）、有梅毒病史者（aOR=2.07 [1.66-2.58]，p<0.001）和住院者（aOR=3.08 [2.03-4.68]，p<0.001）。PLWH 更有可能患有直肠炎（aOR=1.73 [1.26-2.37]，p=0.001）。总死亡率为 3561 例中的 20 例（0.56%）。在 PLWH 和 Mpox 中，住院（p<0.001）和非ART（p<0.001）患者的死亡人数更多。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES

CiteScore

13.10

自引率

1.50%

发文量

203

审稿时长

96 days

期刊介绍： The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.