Investigating the efficacy of Commiphora mukul drops in patients with knee osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial
IF 2.2 4区 医学Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE
Abolqasem Mirzaei , Zahra Jafari , Pardis Mohammadi Pour , Alireza Fazayeli , Alireza Soltanian , Mohammad H. Farzaei
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引用次数: 0
Abstract
Introduction
Knee osteoarthritis is the common joint disease and one of the major causes of pain and disability in the world. Regarding the people tendency to traditional medicine the present study was designed to survey the activity of Commiphora mukul (C. mukul) drops on knee osteoarthritis for the first time.
Methods
The present study was performed as a randomized, double-blind placebo-controlled trial with 70 patients with moderate knee osteoarthritis, which divided into two groups, drug recipients and placebo. Twenty drops were administered to the placebo group and the control group was administered 20 drops of drug twice a day for 2 months. The pain, function and clinical health scores of both groups were measured at the beginning and end of the study with Visual Analogue Scale and knee injury and osteoarthritis outcome score evaluation scales.
Results
The intervention and control groups were similar in terms of age, gender, pain score and knee function before the intervention. Pain intensity in right and left legs was decreased and exhibited statistically significant differences before and after the intervention in both the intervention group (P < 0.001) and the control group (P < 0.01). Five indices of discomfort and dryness, pain, activity and daily activities, exercise and recreation and quality of life in the intervention group, improved (P < 0.001) though in control group the difference between indices were not significant except exercise and recreation.
Discussion/Conclusions
The consumption of C. mukul extract for 2 months was effective in relieving the symptoms of the knee osteoarthritis in patients and improve the quality of life.
期刊介绍:
The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.