STX-bpc: “Brightening” the path to neuronal inhibition

IF 6.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Chemical Biology Pub Date : 2024-07-18 DOI:10.1016/j.chembiol.2024.06.008

Jinxia Wan , Yulong Li

引用次数: 0

Abstract

In this issue of Cell Chemical Biology, Elleman et al.¹ introduce a transformative chemical approach to control neuronal activity with high spatial and temporal resolution. The authors present STX-bpc, a potent neurotoxin that naturally inhibits voltage-gated sodium channels (Na_Vs), complementing available optogenetic methods for manipulating neuronal activity, cellular communication, and behavior.

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STX-bpc："照亮 "神经元抑制之路

在本期的《细胞化学生物学》（Cell Chemical Biology）杂志上，Elleman 等人1 介绍了一种变革性的化学方法，可以高空间和时间分辨率控制神经元活动。作者介绍了一种天然抑制电压门控钠通道（NaVs）的强效神经毒素 STX-bpc，它是对现有光遗传学方法的补充，可用于操纵神经元活动、细胞通讯和行为。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Chemical Biology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

14.70

自引率

2.30%

发文量

143

期刊介绍： Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.