Social vs. individual age-dependent costs of imperfect vaccination

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-15 DOI:10.1016/j.mbs.2024.109259

Fabio A.C.C. Chalub, Paulo Doutor, Paula Patrício, Maria do Céu Soares

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Abstract

In diseases with long-term immunity, vaccination is known to increase the average age at infection as a result of the decrease in the pathogen circulation. This implies that a vaccination campaign can have negative effects when a disease is more costly (financial or health-related costs) for higher ages. This work considers an age-structured population transmission model with imperfect vaccination. We aim to compare the social and individual costs of vaccination, assuming that disease costs are age-dependent, while the disease’s dynamic is age-independent. A model for pathogen deterministic dynamics in a population consisting of juveniles and adults, assumed to be rational agents, is introduced. The parameter region for which vaccination has a positive social impact is fully characterized and the Nash equilibrium of the vaccination game is obtained. Finally, collective strategies designed to promote voluntary vaccination, without compromising social welfare, are discussed.

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不完善疫苗接种的社会成本与个人年龄成本。

众所周知，在具有长期免疫力的疾病中，由于病原体循环的减少，接种疫苗会提高平均感染年龄。这就意味着，当一种疾病对较高年龄段的人来说成本更高（经济成本或与健康相关的成本）时，疫苗接种活动就会产生负面影响。本研究考虑的是不完全接种疫苗的年龄结构人口传播模型。我们旨在比较疫苗接种的社会成本和个人成本，假设疾病成本与年龄有关，而疾病的动态变化与年龄无关。我们引入了一个病原体确定性动态耦合模型，该模型由假定为理性主体的青少年和成年人组成。疫苗接种对社会产生积极影响的参数区域得到了充分表征，疫苗接种博弈的纳什均衡也被求得。最后，讨论了旨在促进自愿接种疫苗而又不损害社会福利的集体策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.