Development of a novel scoring system to predict mortality in canine patients with infection

IF 1.1 3区农林科学 Q3 VETERINARY SCIENCES

Journal of veterinary emergency and critical care Pub Date : 2024-07-18 DOI:10.1111/vec.13405

Mallory V. Horridge DVM, Bridget M. Lyons VMD, DACVECC, Darko Stefanovski BS, MS, PhD, Deborah C. Silverstein BS, DVM, DACVECC

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引用次数: 0

Abstract

Objectives

To develop a novel illness severity scoring system to identify canine patients with infection that are at higher risk of mortality.

Key Findings

Mentation (Modified Glasgow Coma Scale and the Acute Patient Physiologic and Laboratory Evaluation mentation score), heart rate, pH, P_vco₂, potassium, and total plasma protein were found to be associated with mortality on univariate analysis. Logistic regression found that mentation, heart rate, and P_vco₂ combined to form the following score: [(100 × mentation score) + (3 × heart rate) + (10 × P_vco₂], which was predictive of mortality (area under the receiver operating characteristic curve: 0.88). A cutoff of 900 provided a sensitivity of 80% and a specificity of 80%. If the cutoff was changed to 800, the sensitivity was 100% and the specificity was 50%.

Significance

A novel scoring system was developed to predict mortality in hospitalized dogs with confirmed or suspected infection. Further prospective evaluation in a larger patient cohort is necessary to validate this score.

查看原文本刊更多论文

开发新型评分系统，预测犬类感染患者的死亡率。

目的：开发一种新的疾病严重程度评分系统，用于识别死亡风险较高的犬感染患者：开发一种新的疾病严重程度评分系统，以确定死亡率风险较高的犬感染患者：主要研究结果：通过单变量分析发现，精神状态（改良格拉斯哥昏迷量表和急性患者生理和实验室评估精神状态评分）、心率、pH值、Pvco2、血钾和总血浆蛋白与死亡率有关。逻辑回归发现，精神状态、心率和 Pvco2 组合成以下评分：[（100 × 精神状态评分）+（3 × 心率）+（10 × Pvco2]，可预测死亡率（接收器操作特征曲线下面积：0.88）。900 分界点的灵敏度为 80%，特异度为 80%。如果将临界值改为 800，则灵敏度为 100%，特异性为 50%：意义：我们开发了一种新的评分系统来预测确诊或疑似感染的住院犬的死亡率。有必要在更大的患者群中进行进一步的前瞻性评估，以验证该评分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of veterinary emergency and critical care 农林科学-兽医学

CiteScore

2.50

自引率

15.40%

发文量

121

审稿时长

18-36 weeks

期刊介绍： The Journal of Veterinary Emergency and Critical Care’s primary aim is to advance the international clinical standard of care for emergency/critical care patients of all species. The journal’s content is relevant to specialist and non-specialist veterinarians practicing emergency/critical care medicine. The journal achieves it aims by publishing descriptions of unique presentation or management; retrospective and prospective evaluations of prognosis, novel diagnosis, or therapy; translational basic science studies with clinical relevance; in depth reviews of pertinent topics; topical news and letters; and regular themed issues. The journal is the official publication of the Veterinary Emergency and Critical Care Society, the American College of Veterinary Emergency and Critical Care, the European Veterinary Emergency and Critical Care Society, and the European College of Veterinary Emergency and Critical Care. It is a bimonthly publication with international impact and adheres to currently accepted ethical standards.