Mortality risk factors in children with influenza-associated encephalopathy admitted to the paediatric intensive care unit between 2009 and 2021

IF 1.6 4区医学 Q2 PEDIATRICS

Journal of paediatrics and child health Pub Date : 2024-07-18 DOI:10.1111/jpc.16611

Jiajia Bi, Xiaoxin Wu, Jikui Deng

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引用次数: 0

Abstract

Aim

The purpose of this study was to determine the risk factors for death in children with influenza-associated encephalopathy (IAE) in the paediatric intensive care unit (PICU).

Methods

Forty-six paediatric patients with IAE admitted to the PICU at shenzhen Children's Hospital between December 2009 and December 2021 were evaluated. Their clinical characteristics were retrospectively analysed.

Results

A total of 46 patients were diagnosed with influenza A virus infection and encephalopathy. The cases were concentrated in children <5 years of age (27/46, 58.7%). Twenty-nine patients (63.0%) survived and 17 patients (37.0%) died, of which 70.6% (12/17) of the patients died within 1 week of hospitalisation. Thirty-two patients (69.6%) developed neurological symptoms within 1–2 days of fever onset. Common symptoms included fever (45/46, 97.8%), loss of consciousness (39/46, 84.8%), seizures (31/46, 67.4%), cough (19/46, 41.3%), and vomiting (16/46, 34.8%). Multivariate logistic regression analysis indicated that vomiting (odds ratio [OR], 11.005), loss of consciousness (AVPU score: P; OR, 15.871), lymphopenia (OR, 8.964), alanine aminotransferase (>80 IU/L; OR, 32.060) and serum sodium concentration (>145 mmol/L or <135 mmol/L; OR, 16.264) were related to mortality.

Conclusions

The mortality in this study population was 37.0%. Children with IAE who have corresponding clinical manifestations and abnormal examination results in PICU should be warned of the high mortality rate.

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2009年至2021年期间入住儿科重症监护室的流感相关脑病患儿的死亡风险因素。

目的：本研究旨在确定儿科重症监护病房（PICU）中流感相关脑病（IAE）患儿的死亡风险因素：方法：对2009年12月至2021年12月期间入住深圳市儿童医院儿科重症监护室的46名IAE患儿进行评估。结果：共有 46 名患者被诊断为 IAE：结果：共有46名患者被确诊为甲型流感病毒感染合并脑病。病例主要集中在儿童（80 IU/L；OR，32.060）和血清钠浓度（>145 mmol/L或结论）：本研究人群的死亡率为 37.0%。应提醒在 PICU 有相应临床表现和异常检查结果的 IAE 患儿注意高死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of paediatrics and child health 医学-小儿科

CiteScore

2.90

自引率

5.90%

发文量

487

审稿时长

3-6 weeks

期刊介绍： The Journal of Paediatrics and Child Health publishes original research articles of scientific excellence in paediatrics and child health. Research Articles, Case Reports and Letters to the Editor are published, together with invited Reviews, Annotations, Editorial Comments and manuscripts of educational interest.

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