Pancreatic ductal adenocarcinoma microenvironment: Soluble factors and cancer associated fibroblasts as modulators of NK cell functions

IF 3.3 4区医学 Q3 IMMUNOLOGY

Immunology letters Pub Date : 2024-07-15 DOI:10.1016/j.imlet.2024.106898

Simona Carlomagno , Chiara Setti , Fulvia Ortolani , Simona Sivori

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引用次数: 0

Abstract

Pancreatic Ductal Adenocarcinoma (PDAC) is the most frequent pancreatic cancer and represents one of the most aggressive human neoplasms. Typically identified at advance stage disease, most PDAC tumors are unresectable and resistant to standard therapies.

The immunosuppressive microenvironment in PDAC impedes tumor control but a greater understanding of the complex stromal interactions within the tumor microenvironment (TME) and the development of strategies capable of restoring antitumor effector immune responses could be crucial to fight this aggressive tumor and its spread.

Natural Killer (NK) cells play a crucial role in cancer immunosurveillance and represent an attractive target for immunotherapies, both as cell therapy and as a pharmaceutical target.

This review describes some crucial components of the PDAC TME (collagens, soluble factors and fibroblasts) that can influence the presence, phenotype and function of NK cells in PDAC patients tumor tissue. This focused overview highlights the therapeutic relevance of dissecting the complex stromal composition to define new strategies for NK cell-based immunotherapies to improve the treatment of PDAC.

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胰腺导管腺癌微环境：可溶性因子和癌症相关成纤维细胞是 NK 细胞功能的调节剂。

胰腺导管腺癌（PDAC）是最常见的胰腺癌，也是侵袭性最强的人类肿瘤之一。大多数 PDAC 肿瘤通常在疾病晚期才被发现，而且无法切除，对标准疗法具有抗药性。PDAC的免疫抑制微环境阻碍了肿瘤的控制，但进一步了解肿瘤微环境（TME）内复杂的基质相互作用，并开发能够恢复抗肿瘤效应免疫反应的策略，对于抗击这种侵袭性肿瘤及其扩散至关重要。自然杀伤（NK）细胞在癌症免疫监视中起着至关重要的作用，是免疫疗法的一个诱人靶点，既可作为细胞疗法，也可作为药物靶点。本综述介绍了 PDAC TME 的一些关键成分（胶原、可溶性因子和成纤维细胞），这些成分可影响 PDAC 患者肿瘤组织中 NK 细胞的存在、表型和功能。这篇重点突出的综述强调了剖析复杂的基质组成以确定基于 NK 细胞的免疫疗法新策略的治疗意义，从而改善 PDAC 的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunology letters 医学-免疫学

CiteScore

7.60

自引率

0.00%

发文量

审稿时长

44 days

期刊介绍： Immunology Letters provides a vehicle for the speedy publication of experimental papers, (mini)Reviews and Letters to the Editor addressing all aspects of molecular and cellular immunology. The essential criteria for publication will be clarity, experimental soundness and novelty. Results contradictory to current accepted thinking or ideas divergent from actual dogmas will be considered for publication provided that they are based on solid experimental findings. Preference will be given to papers of immediate importance to other investigators, either by their experimental data, new ideas or new methodology. Scientific correspondence to the Editor-in-Chief related to the published papers may also be accepted provided that they are short and scientifically relevant to the papers mentioned, in order to provide a continuing forum for discussion.