Etiological analysis of ocular herpes virus infection.

IF 2.4 3区医学 Q2 OPHTHALMOLOGY

Graefe’s Archive for Clinical and Experimental Ophthalmology Pub Date : 2024-12-01 Epub Date: 2024-07-18 DOI:10.1007/s00417-024-06550-6

Yingyu Li, Pei Zhang, Lina Feng, Yanling Wang, Xuran Dong, Jing Hong

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引用次数: 0

Abstract

Objective: To do the etiological analysis of ocular herps virus infection, revealing the pathogen species and the distribution of different virus types within the eye.

Methods: Samples were collected from 2017 to 2021 at the Department of Ophthalmology, Peking University Third Hospital and tested using real-time PCR for common ocular viruses: herpes simplex virus 1 (HSV-1), cytomegalovirus (CMV), varicella-zoster virus (VZV) and Epstein-Barr virus (EBV). The pathogenesis of the different viruses was classified and analyzed according to the site of infection.

Results: Viral PCR detections were performed on 3627 samples collected over the 5-years and 649 (17.89%) samples contained one or more of the viruses tested. The overall detection rate of CMV was highest at 9.93%. Of all sample types, aqueous humor was the most common (1752 cases), of which 340 were positive (19.41% positive rate). Corneal samples were the next most common, with 1481 cases and 250 positive results (16.88% positive rate). CMV positivity was higher in aqueous humor and corneal samples than other viruses; vitreous body had the highest positive rate at 36.36% (20/55), among which 18 cases were VZV positive.

Conclusions: Distribution of virus types differed among infection sites, with CMV the most common virus type detected in the cornea and aqueous humor, while VZV was the most common virus detected in the vitreous body.

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眼部疱疹病毒感染的病因分析。

目的对眼部疱疹病毒感染进行病原学分析，揭示病原体种类及不同类型病毒在眼内的分布情况：2017年至2021年在北京大学第三医院眼科采集样本，采用实时PCR技术检测常见眼部病毒：单纯疱疹病毒1（HSV-1）、巨细胞病毒（CMV）、水痘-带状疱疹病毒（VZV）和爱泼斯坦-巴氏病毒（EBV）。根据感染部位对不同病毒的致病机理进行了分类和分析：对 5 年间收集的 3627 份样本进行了病毒 PCR 检测，其中 649 份样本（17.89%）含有一种或多种被测病毒。CMV 的总体检出率最高，为 9.93%。在所有样本类型中，房水样本最常见（1752 例），其中 340 例呈阳性（阳性率为 19.41%）。其次是角膜样本，共有 1481 例，其中 250 例呈阳性（阳性率为 16.88%）。与其他病毒相比，CMV 在房水和角膜样本中的阳性率较高；玻璃体的阳性率最高，为 36.36%（20/55），其中 18 例为 VZV 阳性：不同感染部位的病毒类型分布不同，CMV 是在角膜和房水中检测到的最常见病毒类型，而 VZV 则是在玻璃体内检测到的最常见病毒。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Graefe’s Archive for Clinical and Experimental Ophthalmology 医学-眼科学

CiteScore

5.40

自引率

7.40%

发文量

398

审稿时长

3 months

期刊介绍： Graefe''s Archive for Clinical and Experimental Ophthalmology is a distinguished international journal that presents original clinical reports and clini-cally relevant experimental studies. Founded in 1854 by Albrecht von Graefe to serve as a source of useful clinical information and a stimulus for discussion, the journal has published articles by leading ophthalmologists and vision research scientists for more than a century. With peer review by an international Editorial Board and prompt English-language publication, Graefe''s Archive provides rapid dissemination of clinical and clinically related experimental information.