Acidity and hypoxia of tumor microenvironment, a positive interplay in extracellular vesicle release by tumor cells.

IF 6.6 2区 医学 Q1 Medicine
Silvia Peppicelli, Lido Calorini, Francesca Bianchini, Laura Papucci, Lucia Magnelli, Elena Andreucci
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引用次数: 0

Abstract

The complex and continuously evolving features of the tumor microenvironment, varying between tumor histotypes, are characterized by the presence of host cells and tumor cells embedded in a milieu shaped by hypoxia and low pH, resulting from the frequent imbalance between vascularity and tumor cell proliferation. These microenvironmental metabolic stressors play a crucial role in remodeling host cells and tumor cells, contributing to the stimulation of cancer cell heterogeneity, clonal evolution, and multidrug resistance, ultimately leading to progression and metastasis. The extracellular vesicles (EVs), membrane-enclosed structures released into the extracellular milieu by tumor/host cells, are now recognized as critical drivers in the complex intercellular communication between tumor cells and the local cellular components in a hypoxic/acidic microenvironment. Understanding the intricate molecular mechanisms governing the interactions between tumor and host cells within a hypoxic and acidic microenvironment, triggered by the release of EVs, could pave the way for innovative strategies to disrupt the complex interplay of cancer cells with their microenvironment. This approach may contribute to the development of an efficient and safe therapeutic strategy to combat cancer progression. Therefore, we review the major findings on the release of EVs in a hypoxic/acidic tumor microenvironment to appreciate their role in tumor progression toward metastatic disease.

Abstract Image

肿瘤微环境的酸度和缺氧是肿瘤细胞释放细胞外囊泡的积极相互作用。
肿瘤微环境的特征复杂且不断变化,因肿瘤组织类型而异,其特点是宿主细胞和肿瘤细胞嵌入缺氧和低 pH 值的环境中,这是血管和肿瘤细胞增殖之间经常失衡的结果。这些微环境代谢压力因素在宿主细胞和肿瘤细胞的重塑过程中发挥着至关重要的作用,有助于刺激癌细胞的异质性、克隆进化和多药耐药性,最终导致癌细胞的发展和转移。细胞外囊泡(EVs)是肿瘤/宿主细胞释放到细胞外环境中的膜封闭结构,现已被认为是缺氧/酸性微环境中肿瘤细胞与当地细胞成分之间复杂的细胞间交流的关键驱动因素。了解由 EVs 释放引发的缺氧和酸性微环境中肿瘤细胞与宿主细胞之间相互作用的复杂分子机制,可为制定创新策略以破坏癌细胞与其微环境之间的复杂相互作用铺平道路。这种方法可能有助于开发一种高效、安全的治疗策略来对抗癌症进展。因此,我们回顾了在缺氧/酸性肿瘤微环境中释放 EVs 的主要发现,以了解 EVs 在肿瘤向转移性疾病发展过程中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cellular Oncology
Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research
CiteScore
10.40
自引率
1.50%
发文量
0
审稿时长
16 weeks
期刊介绍: The Official Journal of the International Society for Cellular Oncology Focuses on translational research Addresses the conversion of cell biology to clinical applications Cellular Oncology publishes scientific contributions from various biomedical and clinical disciplines involved in basic and translational cancer research on the cell and tissue level, technical and bioinformatics developments in this area, and clinical applications. This includes a variety of fields like genome technology, micro-arrays and other high-throughput techniques, genomic instability, SNP, DNA methylation, signaling pathways, DNA organization, (sub)microscopic imaging, proteomics, bioinformatics, functional effects of genomics, drug design and development, molecular diagnostics and targeted cancer therapies, genotype-phenotype interactions. A major goal is to translate the latest developments in these fields from the research laboratory into routine patient management. To this end Cellular Oncology forms a platform of scientific information exchange between molecular biologists and geneticists, technical developers, pathologists, (medical) oncologists and other clinicians involved in the management of cancer patients. In vitro studies are preferentially supported by validations in tumor tissue with clinicopathological associations.
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