No sex difference in maturation of brain morphology during the perinatal period.

IF 2.7 3区 医学 Q1 ANATOMY & MORPHOLOGY
Brain Structure & Function Pub Date : 2024-11-01 Epub Date: 2024-07-17 DOI:10.1007/s00429-024-02828-x
Yucen Sheng, Ying Wang, Xiaomin Wang, Zhe Zhang, Dalin Zhu, Weihao Zheng
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Abstract

Accumulating evidence have documented sex differences in brain anatomy from early childhood to late adulthood. However, whether sex difference of brain structure emerges in the neonatal brain and how sex modulates the development of cortical morphology during the perinatal stage remains unclear. Here, we utilized T2-weighted MRI from the Developing Human Connectome Project (dHCP) database, consisting of 41 male and 40 female neonates born between 35 and 43 postmenstrual weeks (PMW). Neonates of each sex were arranged in a continuous ascending order of age to capture the progressive changes in cortical thickness and curvature throughout the developmental continuum. The maturational covariance network (MCN) was defined as the coupled developmental fluctuations of morphology measures between cortical regions. We constructed MCNs based on the two features, respectively, to illustrate their developmental interdependencies, and then compared the network topology between sexes. Our results showed that cortical structural development exhibited a localized pattern in both males and females, with no significant sex differences in the developmental trajectory of cortical morphology, overall organization, nodal importance, and modular structure of the MCN. Furthermore, by merging male and female neonates into a unified cohort, we identified evident dependencies influences in structural development between different brain modules using the Granger causality analysis (GCA), emanating from high-order regions toward primary cortices. Our findings demonstrate that the maturational pattern of cortical morphology may not differ between sexes during the perinatal period, and provide evidence for the developmental causality among cortical structures in perinatal brains.

Abstract Image

围产期大脑形态的成熟没有性别差异。
越来越多的证据表明,从幼儿期到成年晚期,大脑解剖结构存在性别差异。然而,新生儿大脑结构的性别差异是否出现以及性别如何调节围产期大脑皮层形态的发育仍不清楚。在此,我们利用发育中人类连接组项目(dHCP)数据库中的 T2 加权核磁共振成像,其中包括 41 名男新生儿和 40 名女新生儿,出生日期介于月经后 35 至 43 周(PMW)之间。每种性别的新生儿按年龄连续递增的顺序排列,以捕捉皮层厚度和曲率在整个发育过程中的渐进变化。成熟协方差网络(MCN)被定义为皮质区域之间形态测量的耦合发育波动。我们分别根据这两个特征构建了MCN,以说明它们在发育过程中的相互依赖关系,然后比较了不同性别之间的网络拓扑结构。结果表明,男性和女性的大脑皮层结构发育都呈现出一种局部模式,在大脑皮层形态的发育轨迹、整体组织、节点重要性以及MCN的模块化结构方面都没有显著的性别差异。此外,通过将男性和女性新生儿合并成一个统一的队列,我们利用格兰杰因果关系分析(GCA)发现了不同大脑模块之间结构发展的明显依赖性影响,这些影响从高阶区域向初级皮层延伸。我们的研究结果表明,在围产期,不同性别的新生儿大脑皮层形态的成熟模式可能没有差异,并为围产期大脑皮层结构之间的发育因果关系提供了证据。
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来源期刊
Brain Structure & Function
Brain Structure & Function 医学-解剖学与形态学
CiteScore
6.00
自引率
6.50%
发文量
168
审稿时长
8 months
期刊介绍: Brain Structure & Function publishes research that provides insight into brain structure−function relationships. Studies published here integrate data spanning from molecular, cellular, developmental, and systems architecture to the neuroanatomy of behavior and cognitive functions. Manuscripts with focus on the spinal cord or the peripheral nervous system are not accepted for publication. Manuscripts with focus on diseases, animal models of diseases, or disease-related mechanisms are only considered for publication, if the findings provide novel insight into the organization and mechanisms of normal brain structure and function.
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