Review on Synthesis of 2-(2-Hydroxyaryl) Benzothiazoles (HBT) for Excited-State Intra-molecular Proton Transfer (ESIPT)-Based Detection of Ions and Biomolecules

IF 8.6 2区 化学 Q1 Chemistry
Amandeep Kaur, R. P. Chaudhary
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引用次数: 0

Abstract

In this review, we present a systematic and comprehensive summary of the recent developments in the synthetic strategies of 2-(2-hydroxyarylsubstituted)-benzothiazole (HBT) framework along with incorporation of various substituents on phenolic and benzothiazole rings which affect the emission process. The literature, spanning the years 2015–2024, on excited-state intramolecular proton transfer (ESIPT)-based studies of HBT derivatives comprising the effects of solvent polarity, substituents, and extended conjugation on fluorophores has been searched. ESIPT, intramolecular charge transfer, and aggregation-induced emissions enable these fluorescent probes to specifically interact with analytes, thereby altering their luminescence characteristics to achieve analyte detection. These fluorescent probes exhibit large Stokes shifts, high quantum yields, and excellent color transitions. Finally, the applications of HBTs as ESIPT-based fluorescent probes for the detection of cations, anions, and biomolecules have been summarized. We anticipate that this review will provide a comprehensive overview of the current state of research in this field and encourage researchers to develop novel ESIPT-based fluorophores with new applications.

Abstract Image

基于激发态分子内质子转移 (ESIPT) 的离子和生物大分子检测的 2-(2-羟基芳基) 苯并噻唑 (HBT) 的合成综述。
在这篇综述中,我们系统而全面地总结了 2-(2-羟基芳基取代)-苯并噻唑(HBT)框架合成策略的最新进展,以及在酚醛环和苯并噻唑环上加入各种取代基对发射过程的影响。我们搜索了 2015-2024 年间基于激发态分子内质子转移(ESIPT)研究 HBT 衍生物的文献,包括溶剂极性、取代基和扩展共轭对荧光团的影响。ESIPT、分子内电荷转移和聚集诱导发射使这些荧光探针能够与分析物发生特异性相互作用,从而改变其发光特性,实现分析物检测。这些荧光探针具有较大的斯托克斯位移、较高的量子产率和出色的颜色转换。最后,我们总结了 HBT 作为基于 ESIPT 的荧光探针在检测阳离子、阴离子和生物分子方面的应用。我们希望这篇综述能全面概述该领域的研究现状,并鼓励研究人员开发基于 ESIPT 的新型荧光探针,以实现新的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Topics in Current Chemistry
Topics in Current Chemistry 化学-化学综合
CiteScore
11.70
自引率
1.20%
发文量
0
审稿时长
6-12 weeks
期刊介绍: Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.
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