Effect of metformin on incidence, recurrence, and mortality in prostate cancer patients: integrating evidence from real-world studies.

IF 5.1 2区 医学 Q1 ONCOLOGY
Yuchen Liu, Qingfang Zhang, Xuan Huang
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Abstract

Purpose: Metformin has been suggested to reduce the risk of cancer. However, previous studies have been inconsistent regarding the relationship between metformin use and the risk of occurrence of prostate cancer (PCa). The purpose of this study was to assess the effect of metformin on clinical outcomes in patients with PCa in a meta-analysis and to explore the possible dose-response relationship.

Methods: A systematic literature search was conducted in 10 electronic databases and 4 registries. The combined relative risks (RRs) were calculated using a random-effects model with 95% confidence interval (CIs) to assess the effect of metformin on the risk of PCa. Relevant subgroup analyses and sensitivity analyses were performed.

Results: The across studies results show that metformin use associated with lower incidence of PCa (RR: 0.82, 95% CI: 0.74-0.91). Metformin use was also found to reduce PCa recurrence, but the results were not statistically significant (RR: 0.97, 95% CI: 0.81-1.15). Metformin use was not associated with PCa mortality (RR: 0.94, 95% CI: 0.81-1.09). The results of subgroup analyses indicated that the type of study was a cohort study and the population came from both Asia and Europe showed that taking metformin reduced the incidence of PCa. A linear correlation was found between the duration of metformin use and its protective effect.

Conclusions: This meta-analysis revealed an independent correlation between metformin use and reduced incidence of PCa. Metformin use was not associated with either PCa recurrence rate or mortality. Furthermore, the effect of metformin on PCa incidence was found to be related to duration.

Abstract Image

二甲双胍对前列腺癌患者发病率、复发率和死亡率的影响:整合来自真实世界研究的证据。
目的:二甲双胍被认为可以降低患癌风险。然而,关于二甲双胍的使用与前列腺癌(PCa)发病风险之间的关系,以往的研究结果并不一致。本研究旨在通过一项荟萃分析评估二甲双胍对PCa患者临床预后的影响,并探讨可能存在的剂量-反应关系:在10个电子数据库和4个登记处进行了系统性文献检索。采用随机效应模型计算合并相对风险(RRs)和95%置信区间(CIs),以评估二甲双胍对PCa风险的影响。研究还进行了相关的亚组分析和敏感性分析:各项研究结果表明,服用二甲双胍可降低 PCa 的发病率(RR:0.82,95% CI:0.74-0.91)。使用二甲双胍还能降低 PCa 复发率,但结果在统计学上并不显著(RR:0.97,95% CI:0.81-1.15)。二甲双胍与 PCa 死亡率无关(RR:0.94,95% CI:0.81-1.09)。亚组分析结果表明,研究类型为队列研究,研究对象来自亚洲和欧洲,结果显示服用二甲双胍可降低 PCa 的发病率。服用二甲双胍的时间长短与其保护作用呈线性相关:这项荟萃分析表明,服用二甲双胍与降低 PCa 发病率之间存在独立的相关性。使用二甲双胍与 PCa 复发率或死亡率均无关。此外,二甲双胍对 PCa 发病率的影响还与持续时间有关。
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来源期刊
Prostate Cancer and Prostatic Diseases
Prostate Cancer and Prostatic Diseases 医学-泌尿学与肾脏学
CiteScore
10.00
自引率
6.20%
发文量
142
审稿时长
6-12 weeks
期刊介绍: Prostate Cancer and Prostatic Diseases covers all aspects of prostatic diseases, in particular prostate cancer, the subject of intensive basic and clinical research world-wide. The journal also reports on exciting new developments being made in diagnosis, surgery, radiotherapy, drug discovery and medical management. Prostate Cancer and Prostatic Diseases is of interest to surgeons, oncologists and clinicians treating patients and to those involved in research into diseases of the prostate. The journal covers the three main areas - prostate cancer, male LUTS and prostatitis. Prostate Cancer and Prostatic Diseases publishes original research articles, reviews, topical comment and critical appraisals of scientific meetings and the latest books. The journal also contains a calendar of forthcoming scientific meetings. The Editors and a distinguished Editorial Board ensure that submitted articles receive fast and efficient attention and are refereed to the highest possible scientific standard. A fast track system is available for topical articles of particular significance.
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