Research on Experimental Hypertension in Prague (1966-2009).

IF 1.9 4区 医学 Q3 PHYSIOLOGY
Physiological research Pub Date : 2024-08-31 Epub Date: 2024-07-17 DOI:10.33549/physiolres.935425
J Kuneš, J Zicha
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Abstract

The study of ontogenetic aspects of water and electrolyte metabolism performed in the Institute of Physiology (Czechoslovak Academy of Sciences) led to the research on the increased susceptibility of immature rats to salt-dependent forms of hypertension since 1966. Hemodynamic studies in developing rats paved the way to the evaluation of hemodynamic mechanisms during the development of genetic hypertension in SHR. A particular attention was focused on altered renal function and kidney damage in both salt and genetic hypertension with a special respect to renin-angiotensin system. Renal damage associated with hypertension progression was in the center of interest of several research groups in Prague. The alterations in ion transport, cell calcium handling and membrane structure as well as their relationship to abnormal lipid metabolism were studied in a close cooperation with laboratories in Munich, Glasgow, Montreal and Paris. The role of NO and oxidative stress in various forms of hypertension was a subject of a joint research with our Slovak colleagues focused mainly on NO-deficient hypertension elicited by chronic L-NAME administration. Finally, we adopted a method enabling us to evaluate the balance of vasoconstrictor and vasodilator mechanisms in BP maintenance. Using this method we demonstrated sympathetic hyperactivity and relative NO deficiency in rats with either salt-dependent or genetic hypertension. At the end of the first decennium of this century we were ready to modify our traditional approach towards modern trends in the research of experimental hypertension. Keywords: Salt-dependent hypertension o Genetic hypertension o Body fluids o Hemodynamics o Ion transport o Cell membrane structure and function o Renal function o Renin-angiotensin systems.

布拉格的实验性高血压研究(1966-2009 年)(回顾)。
自 1966 年以来,捷克斯洛伐克科学院生理学研究所(Institute of Physiology)对水和电解质新陈代谢的本体方面进行了研究,结果发现未成熟大鼠对盐依赖型高血压的易感性增加。发育中大鼠的血液动力学研究为评估 SHR 遗传性高血压发展过程中的血液动力学机制铺平了道路。盐依赖性高血压和遗传性高血压的肾功能改变和肾脏损伤受到特别关注,尤其是肾素-血管紧张素系统。与高血压进展相关的肾损伤是布拉格几个研究小组关注的焦点。通过与慕尼黑、格拉斯哥、蒙特利尔和巴黎的实验室密切合作,研究了离子传输、细胞钙处理和膜结构的改变,以及它们与脂质代谢异常的关系。NO 和氧化应激在各种形式的高血压中的作用是我们与斯洛伐克同事联合研究的一个主题,主要集中在长期服用 L-NAME 引起的 NO 缺失型高血压。最后,我们采用了一种方法来评估血压维持过程中血管收缩和血管舒张机制的平衡。利用这种方法,我们证明了盐依赖性高血压或遗传性高血压大鼠的交感神经功能亢进和氮氧化物相对缺乏。在本世纪第一个十年结束时,我们已经准备好改变传统的研究方法,以适应现代实验性高血压研究的发展趋势。
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来源期刊
Physiological research
Physiological research 医学-生理学
CiteScore
4.00
自引率
4.80%
发文量
108
审稿时长
3 months
期刊介绍: Physiological Research is a peer reviewed Open Access journal that publishes articles on normal and pathological physiology, biochemistry, biophysics, and pharmacology. Authors can submit original, previously unpublished research articles, review articles, rapid or short communications. Instructions for Authors - Respect the instructions carefully when submitting your manuscript. Submitted manuscripts or revised manuscripts that do not follow these Instructions will not be included into the peer-review process. The articles are available in full versions as pdf files beginning with volume 40, 1991. The journal publishes the online Ahead of Print /Pre-Press version of the articles that are searchable in Medline and can be cited.
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