Myringoplasty Using Human Birth Tissue Allografts to Repair Large Tympanic Membrane Perforations.

IF 2.6 3区 医学 Q1 OTORHINOLARYNGOLOGY
Otolaryngology- Head and Neck Surgery Pub Date : 2024-12-01 Epub Date: 2024-07-17 DOI:10.1002/ohn.905
Nickolas A Alsup, Kyle P Davis, Gresham T Richter, Larry D Hartzell
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引用次数: 0

Abstract

Objective: Examine outcomes among a series of pediatric patients who underwent myringoplasty using human birth tissue (BT) for repair of large tympanic membrane (TM) perforations.

Study design: Case series.

Setting: Single-institution pediatric hospital.

Methods: Retrospective chart review of patients treated with BT during a 4-year study period. Subjects who underwent myringoplasty for large (size 40% or greater) TM perforations were included for this study. Patients with a stable perforation of at least 1 month's duration preoperatively who then followed up for at least 3 months postoperatively met inclusion criteria.

Results: Six subjects were included in this study. One subject underwent bilateral repair; thus, this series includes a total of 7 perforations. TM perforations ranged from 40% to 70% of the TM. At initial follow-up (median of 2 months), 5 of the 7 perforations had healed. One of these 5 had evidence of a 10% recurrent perforation at 5 months, which subsequently healed. Of the 2 patients not healed at initial follow-up, 1 had only a residual pinpoint perforation that subsequently healed; the other had a persistent 30% perforation that was possibly related to their postoperative recovery period, which was complicated by a respiratory viral illness.

Conclusion: For large TM perforations, myringoplasty with BT grafts may be a viable alternative to longer, more invasive procedures like tympanoplasty. Larger, randomized, prospective studies are needed.

使用人类胎儿组织异体移植修复鼓膜大面积穿孔的鼓膜成形术
研究目的研究设计:病例系列:研究设计:病例系列:研究设计:病例系列:方法:对 4 年研究期间接受 BT 治疗的患者进行回顾性病历审查。研究对象包括因 TM 大面积穿孔(大小为 40% 或以上)而接受耳膜成形术的患者。术前穿孔稳定至少 1 个月,术后随访至少 3 个月的患者符合纳入标准:本研究共纳入六名受试者。结果:本研究共纳入六名受试者,其中一名受试者接受了双侧修复术,因此本系列共包括七例穿孔。颞下颌关节穿孔占颞下颌关节的 40% 至 70%。在最初的随访中(中位数为 2 个月),7 个穿孔中有 5 个已经愈合。其中一名患者在 5 个月时有证据显示穿孔复发了 10%,随后痊愈。在初次随访时未痊愈的两名患者中,一名患者仅有一个残留的针尖穿孔,随后痊愈;另一名患者有一个持续存在的30%穿孔,可能与术后恢复期有关,术后恢复期因呼吸道病毒性疾病而变得复杂:结论:对于大面积的鼓室穿孔,使用 BT 移植物进行鼓室成形术可能是一种可行的替代方法,可替代鼓室成形术等时间更长、创伤更大的手术。需要进行更大规模的随机前瞻性研究。
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来源期刊
Otolaryngology- Head and Neck Surgery
Otolaryngology- Head and Neck Surgery 医学-耳鼻喉科学
CiteScore
6.70
自引率
2.90%
发文量
250
审稿时长
2-4 weeks
期刊介绍: Otolaryngology–Head and Neck Surgery (OTO-HNS) is the official peer-reviewed publication of the American Academy of Otolaryngology–Head and Neck Surgery Foundation. The mission of Otolaryngology–Head and Neck Surgery is to publish contemporary, ethical, clinically relevant information in otolaryngology, head and neck surgery (ear, nose, throat, head, and neck disorders) that can be used by otolaryngologists, clinicians, scientists, and specialists to improve patient care and public health.
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