Efficacy of acupuncture for allergic rhinitis in children: Systematic review and meta‑analysis with trial sequential analysis

IF 7.2 2区医学 Q1 OTORHINOLARYNGOLOGY

International Forum of Allergy & Rhinology Pub Date : 2024-07-17 DOI:10.1002/alr.23414

Qinwen Xiao PhD, Zhichao Ni MD, Rongyu Wang PhD, Wen Jiang MD, Jinyao Yuan MD

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引用次数: 0

Abstract

Background

Acupuncture has been shown for the treatment of allergic rhinitis in previous studies. Nevertheless, relevant evidence was lacked for paediatric patients with allergic rhinitis. We aim to validate the efficacy of acupuncture for allergic rhinitis in children by meta-analysis and trial sequence analysis.

Method

Comprehensive search of eight databases were conducted until August 27, 2023. Randomized controlled trials comparing acupuncture alone or in combination with drugs versus medication in children with AR were included. The primary outcome was total nasal symptom score (TNSS). The secondary outcomes were serum immunoglobulin E levels, and relapse rates.

Results

Thirteen studies involving 1186 participants were included. In results, acupuncture group (AC group) versus medication group (Med group) shows no significant difference in the treatment of AR in children (risk ratio [RR] = 1.10, 95% CI = 0.97 to 1.24, p = 0.13), while TSA suggested the included sample size did not exceed required information size (RIS). Significant differences were found between the AC + Med group versus the Med group (RR = 1.29, 95% CI = 1.17 to 1.42, p < 0.00001), with sufficient sample size. Results in serum IgE after treatment which favored the Med group (MD = 51.94, 95% CI [22.24, 81.65], p = 0.0006). In terms of relapse rate, The AC group had a lower relapse rate than the Med group (RR = 0.40, 95% CI = 0.26–0.63, p < 0.0001).

Conclusions

Acupuncture is an efficacious treatment for allergic rhinitis in children, but this conclusion might be limited by the generally low quality of evidence. TSA suggested additional high-quality trials with larger sample sizes and longer treatment durations were needed.

查看原文本刊更多论文

针灸治疗儿童过敏性鼻炎的疗效：系统回顾和荟萃分析与试验序列分析。

背景：以往的研究表明，针灸可用于治疗过敏性鼻炎。然而，针灸治疗儿童过敏性鼻炎缺乏相关证据。我们旨在通过荟萃分析和试验序列分析验证针灸治疗儿童过敏性鼻炎的疗效：方法：截至 2023 年 8 月 27 日，我们对 8 个数据库进行了全面检索。方法：截至 2023 年 8 月 27 日，在 8 个数据库中进行了全面搜索，纳入了对儿童过敏性鼻炎患者进行针灸单独治疗或联合用药与药物治疗比较的随机对照试验。主要结果为鼻部症状总评分（TNSS）。次要结果为血清免疫球蛋白 E 水平和复发率：结果：共纳入 13 项研究，涉及 1186 名参与者。结果显示，针灸组（AC 组）与药物组（Med 组）在治疗儿童 AR 方面无显著差异（风险比 [RR] = 1.10，95% CI = 0.97 至 1.24，P = 0.13），而 TSA 表明纳入的样本量未超过所需的信息量（RIS）。在样本量充足的情况下，AC + Med 组与 Med 组之间存在显著差异（RR = 1.29，95% CI = 1.17 至 1.42，p < 0.00001）。治疗后血清 IgE 的结果有利于 Med 组（MD = 51.94，95% CI [22.24，81.65]，p = 0.0006）。在复发率方面，针灸组的复发率低于药物组（RR = 0.40，95% CI = 0.26-0.63，P < 0.0001）：结论：针灸是治疗儿童过敏性鼻炎的有效方法，但这一结论可能因证据质量普遍较低而受到限制。TSA建议需要更多样本量更大、疗程更长的高质量试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Forum of Allergy & Rhinology OTORHINOLARYNGOLOGY-

CiteScore

11.70

自引率

10.90%

发文量

185

审稿时长

6-12 weeks

期刊介绍： International Forum of Allergy & Rhinologyis a peer-reviewed scientific journal, and the Official Journal of the American Rhinologic Society and the American Academy of Otolaryngic Allergy. International Forum of Allergy Rhinology provides a forum for clinical researchers, basic scientists, clinicians, and others to publish original research and explore controversies in the medical and surgical treatment of patients with otolaryngic allergy, rhinologic, and skull base conditions. The application of current research to the management of otolaryngic allergy, rhinologic, and skull base diseases and the need for further investigation will be highlighted.