Bioengineered mesenchymal stem cell-derived exosomes: emerging strategies for diabetic wound healing.

IF 6.3 1区医学 Q1 DERMATOLOGY

Burns & Trauma Pub Date : 2024-07-16 eCollection Date: 2024-01-01 DOI:10.1093/burnst/tkae030

Lihua Liu, Dewu Liu

{"title":"Bioengineered mesenchymal stem cell-derived exosomes: emerging strategies for diabetic wound healing.","authors":"Lihua Liu, Dewu Liu","doi":"10.1093/burnst/tkae030","DOIUrl":null,"url":null,"abstract":"<p><p>Diabetic wounds are among the most common complications of diabetes mellitus and their healing process can be delayed due to persistent inflammatory reactions, bacterial infections, damaged vascularization and impaired cell proliferation, which casts a blight on patients'health and quality of life. Therefore, new strategies to accelerate diabetic wound healing are being positively explored. Exosomes derived from mesenchymal stem cells (MSC-Exos) can inherit the therapeutic and reparative abilities of stem cells and play a crucial role in diabetic wound healing. However, poor targeting, low concentrations of therapeutic molecules, easy removal from wounds and limited yield of MSC-Exos are challenging for clinical applications. Bioengineering techniques have recently gained attention for their ability to enhance the efficacy and yield of MSC-Exos. In this review, we summarise the role of MSC-Exos in diabetic wound healing and focus on three bioengineering strategies, namely, parental MSC-Exos engineering, direct MSC-Exos engineering and MSC-Exos combined with biomaterials. Furthermore, the application of bioengineered MSC-Exos in diabetic wound healing is reviewed. Finally, we discuss the future prospects of bioengineered MSC-Exos, providing new insights into the exploration of therapeutic strategies.</p>","PeriodicalId":9553,"journal":{"name":"Burns & Trauma","volume":"12 ","pages":"tkae030"},"PeriodicalIF":6.3000,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250359/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Burns & Trauma","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/burnst/tkae030","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Diabetic wounds are among the most common complications of diabetes mellitus and their healing process can be delayed due to persistent inflammatory reactions, bacterial infections, damaged vascularization and impaired cell proliferation, which casts a blight on patients'health and quality of life. Therefore, new strategies to accelerate diabetic wound healing are being positively explored. Exosomes derived from mesenchymal stem cells (MSC-Exos) can inherit the therapeutic and reparative abilities of stem cells and play a crucial role in diabetic wound healing. However, poor targeting, low concentrations of therapeutic molecules, easy removal from wounds and limited yield of MSC-Exos are challenging for clinical applications. Bioengineering techniques have recently gained attention for their ability to enhance the efficacy and yield of MSC-Exos. In this review, we summarise the role of MSC-Exos in diabetic wound healing and focus on three bioengineering strategies, namely, parental MSC-Exos engineering, direct MSC-Exos engineering and MSC-Exos combined with biomaterials. Furthermore, the application of bioengineered MSC-Exos in diabetic wound healing is reviewed. Finally, we discuss the future prospects of bioengineered MSC-Exos, providing new insights into the exploration of therapeutic strategies.

查看原文本刊更多论文

生物工程间充质干细胞衍生的外泌体：糖尿病伤口愈合的新策略。

糖尿病伤口是糖尿病最常见的并发症之一，其愈合过程会因持续的炎症反应、细菌感染、血管受损和细胞增殖受损而延迟，给患者的健康和生活质量造成影响。因此，人们正在积极探索加速糖尿病伤口愈合的新策略。间充质干细胞衍生的外泌体（MSC-Exos）可继承干细胞的治疗和修复能力，在糖尿病伤口愈合中发挥重要作用。然而，间充质干细胞内含物的靶向性差、治疗分子浓度低、容易从伤口中清除以及产量有限等问题给临床应用带来了挑战。最近，生物工程技术因能提高间充质干细胞的疗效和产量而备受关注。在这篇综述中，我们总结了间充质干细胞-Exos 在糖尿病伤口愈合中的作用，并重点介绍了三种生物工程策略，即亲间质干细胞-Exos 工程、直接间充质干细胞-Exos 工程和间充质干细胞-Exos 与生物材料相结合。此外，还综述了生物工程间充质干细胞-外胚层在糖尿病伤口愈合中的应用。最后，我们讨论了生物工程间充质干细胞-Exos 的未来前景，为探索治疗策略提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Burns & Trauma 医学-皮肤病学

CiteScore

8.40

自引率

9.40%

发文量

186

审稿时长

6 weeks

期刊介绍： The first open access journal in the field of burns and trauma injury in the Asia-Pacific region, Burns & Trauma publishes the latest developments in basic, clinical and translational research in the field. With a special focus on prevention, clinical treatment and basic research, the journal welcomes submissions in various aspects of biomaterials, tissue engineering, stem cells, critical care, immunobiology, skin transplantation, and the prevention and regeneration of burns and trauma injuries. With an expert Editorial Board and a team of dedicated scientific editors, the journal enjoys a large readership and is supported by Southwest Hospital, which covers authors'' article processing charges.