The paper presents a new type of weakly nonlinear two-scale model of controllable periodic porous piezoelectric structures saturated by Newtonian fluids. The flow is propelled by peristaltic deformation of microchannels which is induced due to piezoelectric segments embedded in the microstructure and locally actuated by voltage waves. The homogenization is employed to derive a macroscopic model of the poroelastic medium with effective parameters modified by piezoelectric properties of the skeleton. To capture the peristaltic pumping, the nonlinearity associated with deforming configuration must be respected. In the macroscopic model, this nonlinearity is introduced through homogenized coefficients depending on the deforming micro-configurations. For this, linear expansions based on the sensitivity analysis of the homogenized coefficients with respect to deformation induced by the macroscopic quantities are employed. This enables to avoid the two-scale tight coupling of the macro- and microproblems otherwise needed in nonlinear problems. The derived reduced-order model is implemented and verified using direct numerical simulations of the periodic heterogeneous medium. Numerical results demonstrate the peristaltic driven fluid propulsion in response to the electric actuation and the efficiency of the proposed treatment of the nonlinearity. The paper shows new perspectives in homogenization-based computationally efficient modelling of weakly nonlinear problems where continuum microstructures are perturbed by coupled fields.