Nano-enhanced nature medicine for ischemic stroke: Opportunities and challenges

Jihao Yang , Lingyi Guo , Jun Liao , Huaqiang Yi
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引用次数: 0

Abstract

Ischemic stroke (IS), a major cause of death and disability globally, requires innovative therapeutic approaches due to its complex pathology. Nature medicine (NM) offers promising treatments through its bioactive compounds, which target the multifaceted nature of stroke-induced damage. However, the clinical application of NM is limited by challenges in bioavailability and specificity. This review article presents an advanced perspective on integrating nanotechnology with NM to create potent nanodelivery systems for ischemic stroke treatment. We highlight the pathological underpinnings of ischemic stroke, including oxidative stress, inflammation, and apoptosis, and discuss how NM compounds offer targeted mitigation strategies. By incorporating nanodelivery platforms, such as liposomes and nanoparticles, these NM -based treatments can achieve enhanced targeting, solubility, and controlled release, significantly improving therapeutic outcomes while reducing side effects. Despite promising developments, the translation of nano-enhanced NM into clinical practice faces obstacles, including manufacturing scalability, regulatory approval, and safety evaluations. This review emphasizes the potential of combining nanotechnology with NM to advance ischemic stroke therapy, calling for integrated research efforts to overcome existing barriers and fully realize the clinical benefits of this innovative approach.

Abstract Image

治疗缺血性中风的纳米增强自然医学:机遇与挑战
缺血性中风(IS)是全球死亡和残疾的主要原因,由于其病理复杂,需要创新的治疗方法。自然医学(NM)通过其生物活性化合物针对中风引起的多方面损伤提供了有前景的治疗方法。然而,由于生物利用度和特异性方面的挑战,NM 的临床应用受到了限制。这篇综述文章以先进的视角介绍了如何将纳米技术与 NM 相结合,以创建用于缺血性中风治疗的强效纳米给药系统。我们强调了缺血性中风的病理基础,包括氧化应激、炎症和细胞凋亡,并讨论了 NM 化合物如何提供有针对性的缓解策略。通过结合脂质体和纳米颗粒等纳米给药平台,这些基于 NM 的疗法可以实现更强的靶向性、溶解性和控释性,从而在减少副作用的同时显著提高治疗效果。尽管发展前景广阔,但将纳米增强型 NM 转化为临床实践仍面临重重障碍,包括生产的可扩展性、监管审批和安全性评估。本综述强调了纳米技术与 NM 的结合在推进缺血性中风治疗方面的潜力,呼吁开展综合研究,以克服现有障碍,充分实现这种创新方法的临床益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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