VDR polymorphism and its correlation with chronic periodontitis – An updated meta – Analysis

Abstract

The scientific evidences suggest that the common polymorphism in vitamin D receptors (VDR) such as ApaI (rs7975232), BsmI (rs1544410), TaqI (rs731236), and FokI (rs2228570) may influence the risk of chronic periodontitis (CP) however the existing studies have inconclusive results. The present current aim to perform a meta – analysis of the published studies to determine the association of VDR polymorphism with CP susceptibility. An extensive literature search was conducted on various database to find the relevant studies and the crude odds ratio (OR) with 95% confidence interval was calculated. Twenty-two case control studies were included in the study with 2083 cases and 2013 control for TaqI, 989 cases and 722 control for FokI, 1240 cases and 1026 control for BsmI and 972 cases and 961 control for ApaI polymorphism. The overall analysis reported an increased association of CP with the FokI only under dominant model [1.42 (1.12–1.79); 0.002]. The other polymorphism - ApaI, BsmI, and TaqI did not report any significant association in the overall analysis however BsmI and TaqI was associated with CP risk in subgroup analysis. The TaqI polymorphism showed an increased risk of developing CP in African population under allelic [2.00(1.09–3.65)0.024], recessive [10.21 (1.25–82.8)0.029], homozygous [13.75 (1.54–122.0)0.018] and heterozygous [8.80 (1.06–73.0) 0.04] model however the association cannot be concluded as there were fewer studies. The presence of mutant allele of BsmI polymorphism demonstrated a reduced risk of developing CP among Asian under recessive [0.54 (0.29–0.99)0.047] and homozygous [0.49 (0.25–0.94) 0.034] model. The meta – analysis indicate the association of major VDR polymorphism with the development of CP is population specific.