Enhanced biosafety, anticancer and antibacterial photodynamic activities using silver-pyropheophorbide-a nanoconjugates.

Nanomedicine (London, England) Pub Date : 2024-07-16 DOI:10.1080/17435889.2024.2370226

Tabbisa Namulinda, Zhi-Bing Song, Yi-Jia Yan, Min Zhang, Gennady A Meerovich, Davor Margetic, Zhi-Long Chen

{"title":"Enhanced biosafety, anticancer and antibacterial photodynamic activities using silver-pyropheophorbide-a nanoconjugates.","authors":"Tabbisa Namulinda, Zhi-Bing Song, Yi-Jia Yan, Min Zhang, Gennady A Meerovich, Davor Margetic, Zhi-Long Chen","doi":"10.1080/17435889.2024.2370226","DOIUrl":null,"url":null,"abstract":"Aim: A study of the enhancement of photodynamic activities of pyropheophorbide-a using PG-Ag-PPa nanoconjugates. Materials & methods: The nanoconjugates were formulated from silver nanoparticles and PPa via amide linkage, then characterized, and their photodynamic activities were examined. Results: The nanoconjugates displayed a higher rate of reactive oxygen species generation, commendable cellular uptake by Eca-109 cancer cells, higher photocytotoxicity toward the cancer cells and better bio-safety. They revealed strong antibacterial activity against Escherichia coli following internal reactive oxygen species generation and membrane disintegration. The in vivo anticancer studies confirmed higher cytotoxicity of the nanoconjugates toward cancer cells and better safety than PPa. Conclusion: Therefore, PG-Ag-PPa nanoconjugates could be considered potential nano photosensitizers for photodynamic therapy of tumors and bacterial infection with good bio-safety.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomedicine (London, England)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/17435889.2024.2370226","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Aim: A study of the enhancement of photodynamic activities of pyropheophorbide-a using PG-Ag-PPa nanoconjugates. Materials & methods: The nanoconjugates were formulated from silver nanoparticles and PPa via amide linkage, then characterized, and their photodynamic activities were examined. Results: The nanoconjugates displayed a higher rate of reactive oxygen species generation, commendable cellular uptake by Eca-109 cancer cells, higher photocytotoxicity toward the cancer cells and better bio-safety. They revealed strong antibacterial activity against Escherichia coli following internal reactive oxygen species generation and membrane disintegration. The in vivo anticancer studies confirmed higher cytotoxicity of the nanoconjugates toward cancer cells and better safety than PPa. Conclusion: Therefore, PG-Ag-PPa nanoconjugates could be considered potential nano photosensitizers for photodynamic therapy of tumors and bacterial infection with good bio-safety.

查看原文本刊更多论文

利用银-pyropheophorbide-a 纳米共轭物增强生物安全性、抗癌和抗菌光动力活性。

目的：利用 PG-Ag-PPa 纳米共轭物增强焦磷酸-a 的光动力活性。材料与方法：将银纳米颗粒和 PPa 通过酰胺连接配制成纳米共轭物，然后对其进行表征，并考察其光动力活性。结果纳米共轭物具有更高的活性氧生成率、Eca-109 癌细胞摄取率、对癌细胞的光毒性和生物安全性。在产生内部活性氧和膜解体后，它们对大肠杆菌具有很强的抗菌活性。体内抗癌研究证实，与 PPa 相比，纳米共轭物对癌细胞具有更高的细胞毒性和更好的安全性。结论因此，PG-Ag-PPa 纳米共轭物可被视为潜在的纳米光敏剂，用于光动力治疗肿瘤和细菌感染，具有良好的生物安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nanomedicine (London, England)

自引率

0.00%

发文量

文献相关原料

公司名称	产品信息	采购帮参考价格