GRAPPA 2023 Basic Science Workshop: What to Expect From Animal Models for Psoriatic Arthritis and Psoriasis.

IF 3.6 2区 医学 Q2 RHEUMATOLOGY
Margot Van Mechelen, Siba P Raychaudhuri, Smriti K Raychaudhuri, Kurt de Vlam
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引用次数: 0

Abstract

Animal models help to drive research into psoriasis and psoriatic arthritis (PsA), particularly when studies in humans are not feasible. There are no animal models that perfectly mimic psoriatic disease (PsD) and so the pros and cons of each existing model must be considered for appropriate experimental design. Roughly, the existing animal models for PsD can be divided into 4 categories: (1) spontaneous models, (2) transgenic models, (3) inducible models, and (4) xenotransplantation models. Animal models in PsD are extremely important for dissecting and understanding molecular mechanisms of the disease process and for developing novel drugs. Animal models remain highly valuable for research in PsD in 2 scenarios. The first scenario is when complex interventions or analyses are required that are not feasible in humans due to technical, safety, or economic reasons. The second is when well-controlled study environments are required, such as dietary modifications, that would be challenging in humans. This topic was presented as part of the basic science workshops during the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2023 annual meeting.

GRAPPA 2023 基础科学研讨会:对银屑病关节炎和银屑病动物模型的期待。
动物模型有助于推动银屑病和银屑病关节炎(PsA)的研究,尤其是在无法进行人体研究的情况下。目前还没有完全模拟银屑病(PsD)的动物模型,因此必须考虑每种现有模型的优缺点,以进行适当的实验设计。现有的银屑病动物模型大致可分为四类:(1)自发模型;(2)转基因模型;(3)诱导模型;(4)异种移植模型。PsD 动物模型对于剖析和了解疾病过程的分子机制以及开发新型药物极为重要。在两种情况下,动物模型对 PsD 的研究仍具有很高的价值。第一种情况是需要进行复杂的干预或分析,但由于技术、安全或经济原因,在人类身上并不可行。第二种情况是需要控制良好的研究环境,如饮食调整,而这在人类身上是具有挑战性的。这一主题是银屑病和银屑病关节炎研究与评估小组(GRAPPA)2023 年年会基础科学研讨会的一部分。
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来源期刊
Journal of Rheumatology
Journal of Rheumatology 医学-风湿病学
CiteScore
6.50
自引率
5.10%
发文量
285
审稿时长
1 months
期刊介绍: The Journal of Rheumatology is a monthly international serial edited by Earl D. Silverman. The Journal features research articles on clinical subjects from scientists working in rheumatology and related fields, as well as proceedings of meetings as supplements to regular issues. Highlights of our 41 years serving Rheumatology include: groundbreaking and provocative editorials such as "Inverting the Pyramid," renowned Pediatric Rheumatology, proceedings of OMERACT and the Canadian Rheumatology Association, Cochrane Musculoskeletal Reviews, and supplements on emerging therapies.
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