Health-related quality of life and utility values among patients with anxiety and/or depression in a low-income tertiary care setting: a cross-sectional analysis.

IF 3.3 3区医学 Q1 HEALTH CARE SCIENCES & SERVICES

Quality of Life Research Pub Date : 2024-10-01 Epub Date: 2024-07-16 DOI:10.1007/s11136-024-03735-8

Yared Belete Belay, Cathrine Mihalopoulos, Yong Yi Lee, Lidia Engel

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Abstract

Objectives: To describe the health-related quality of life (HRQoL), estimate the associated health state utility values (HSUVs) and explore factors associated with HRQoL of patients with anxiety and/or depression in a resource-limited hospital setting.

Methods: A cross-sectional survey involving 462 participants was conducted in a hospital setting. The Amharic version of the EQ-5D-5 L assessed HRQoL, while the GAD-7 and PHQ-9 measured severity of anxiety and depression symptoms respectively. HSUVs were analysed based on clinical and demographic profiles; mean differences were compared using t-tests and one-way ANOVA; Scheffe's post hoc comparisons and effect sizes (Cohen's d statistic) were used to assess the magnitude of group differences. Factors associated with HRQoL were explored using regression analysis.

Results: The mean HSUV was 0.87 (SD = 0.17) and the EQ VAS was 71.4 (SD = 19.1). Patients with both anxiety and depression scored significantly lower (HSUV = 0.83 [0.16], EQ VAS = 64.4 [17.9]) compared to those with either anxiety only (HSUV = 0.88 [0.17], EQ VAS = 75.3 [17.9]) or depression only (HSUV = 0.89 [0.18], EQ VAS 74.4 [19.7]). Males had slightly higher mean scores than females, while those aged 18-35 years demonstrated the highest scores on both the EQ-5D-5 L and EQ VAS. Older age (β=-0.002), higher PHQ-9 scores (β=-0.008) and comorbid hypertension (β=-0.07) associated with lower HSUVs. Lower EQ VAS scores were associated with being female (β=-4.4), having comorbid hypertension (β=-7.4) and higher PHQ-9 scores (β=-0.86), while a positive association was found with having 'more than enough' income (β = 11.8).

Conclusions: Older age, severity or co-diagnosis of anxiety or depression and comorbid conditions were associated with lower HRQoL, highlighting the need for better interventions to improve the HRQoL of patients with anxiety and depression in Ethiopia.

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低收入三级医疗机构焦虑症和/或抑郁症患者的健康相关生活质量和效用值：横断面分析。

目的描述资源有限的医院环境中焦虑和/或抑郁症患者的健康相关生活质量（HRQoL），估算相关的健康状态效用值（HSUV），并探讨与 HRQoL 相关的因素：在医院环境中进行了一项横断面调查，共有 462 人参与。阿姆哈拉语版 EQ-5D-5 L 评估 HRQoL，GAD-7 和 PHQ-9 分别测量焦虑和抑郁症状的严重程度。根据临床和人口统计学特征对 HSUV 进行分析；使用 t 检验和单因素方差分析比较平均差异；使用 Scheffe 事后比较和效应大小（Cohen's d 统计量）评估群体差异的程度。利用回归分析探讨了与 HRQoL 相关的因素：HSUV 平均值为 0.87（SD = 0.17），EQ VAS 平均值为 71.4（SD = 19.1）。与仅患有焦虑症（HSUV = 0.88 [0.17]，EQ VAS = 75.3 [17.9]）或仅患有抑郁症（HSUV = 0.89 [0.18]，EQ VAS 74.4 [19.7]）的患者相比，同时患有焦虑症和抑郁症的患者得分明显较低（HSUV = 0.83 [0.16]，EQ VAS = 64.4 [17.9]）。男性的平均得分略高于女性，而 18-35 岁人群在 EQ-5D-5 L 和 EQ VAS 上的得分最高。年龄越大（β=-0.002）、PHQ-9 得分越高（β=-0.008）和合并高血压（β=-0.07），HSUV 越低。较低的 EQ VAS 分数与女性（β=-4.4）、合并高血压（β=-7.4）和较高的 PHQ-9 分数（β=-0.86）相关，而与收入 "绰绰有余"（β=11.8）呈正相关：结论：年龄较大、焦虑或抑郁的严重程度或合并诊断以及并发症与较低的 HRQoL 有关，这表明需要采取更好的干预措施来改善埃塞俄比亚焦虑和抑郁患者的 HRQoL。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Quality of Life Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

8.60%

发文量

224

审稿时长

3-8 weeks

期刊介绍： Quality of Life Research is an international, multidisciplinary journal devoted to the rapid communication of original research, theoretical articles and methodological reports related to the field of quality of life, in all the health sciences. The journal also offers editorials, literature, book and software reviews, correspondence and abstracts of conferences. Quality of life has become a prominent issue in biometry, philosophy, social science, clinical medicine, health services and outcomes research. The journal''s scope reflects the wide application of quality of life assessment and research in the biological and social sciences. All original work is subject to peer review for originality, scientific quality and relevance to a broad readership. This is an official journal of the International Society of Quality of Life Research.