Effects of high-intensity interval training on cardiometabolic biomarkers in patients with prostate cancer undergoing active surveillance: a randomized controlled trial.

IF 5.1 2区 医学 Q1 ONCOLOGY
Dong-Woo Kang, Catherine J Field, Dhruvesh Patel, Adrian S Fairey, Normand G Boulé, Christina M Dieli-Conwright, Kerry S Courneya
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引用次数: 0

Abstract

Purpose: To report the effects of a 12-week high-intensity interval training (HIIT) program on cardiometabolic biomarkers in patients with prostate cancer on active surveillance (AS) from the Exercise During Active Surveillance for Prostate Cancer (ERASE) Trial.

Methods: Fifty-two men with prostate cancer on AS were randomized to either an exercise (HIIT; n = 26) or usual care (UC; n = 26) group. The HIIT intervention consisted of progressive, supervised, aerobic HIIT at an intensity of 85 to 95% VO2peak for 28 to 40 min per session performed three times/week for 12 weeks. Blood samples were collected at baseline and postintervention to analyze cardiometabolic biomarkers. Analysis of covariance was used to examine between-group mean differences.

Results: Blood data were obtained from 49/52 (94%) participants at postintervention. Participants were aged 63.4 ± 7.1 years and 40% were obese. The HIIT group attended 96% of the planned exercise sessions. No significant between-group changes in weight were observed after the intervention. Compared to UC, HIIT significantly improved total cholesterol (-0.40 mmol/L; 95% confidence interval[CI], -0.70 to -0.10; p = 0.011), non-high-density lipoprotein-c (-0.35 mmol/L; 95% CI, -0.60 to -0.11; p = 0.006), insulin (-13.6 pmol/L; 95% CI, -25.3 to -1.8; p = 0.025), insulin-like growth factor (IGF)-1 (-15.0 ng/mL; 95% CI, -29.9 to -0.1; p = 0.048), and IGF binding protein (IGFBP)-3 (152.3 ng/mL; 95% CI, 12.6 to 292.1; p = 0.033). No significant differences were observed for fasting glucose, HbA1c, other lipid markers, IGFBP-1, adiponectin, and leptin.

Conclusions: The ERASE Trial showed that a 12-week aerobic HIIT program improved several cardiometabolic biomarkers in patients with prostate cancer on AS that may contribute to cardiovascular health benefits and potentially influence signaling pathways in the progression of prostate cancer. Further research is needed to confirm the effects of exercise on cardiometabolic markers in men with prostate cancer on AS and determine if these effects are associated with improved long-term clinical outcomes.

高强度间歇训练对接受主动监测的前列腺癌患者心脏代谢生物标志物的影响:随机对照试验。
目的:报告为期12周的高强度间歇训练(HIIT)计划对前列腺癌患者心脏代谢生物标志物的影响:52名接受主动监测的前列腺癌男性患者被随机分配到运动组(HIIT;26人)或常规护理组(UC;26人)。HIIT干预包括循序渐进、有监督的有氧HIIT,强度为85%至95% VO2peak,每次28至40分钟,每周三次,持续12周。在基线和干预后收集血液样本以分析心脏代谢生物标志物。采用协方差分析法检验组间平均差异:49/52(94%)名参与者在干预后获得了血液数据。参与者的年龄为(63.4 ± 7.1)岁,40%为肥胖。HIIT 组参加了计划运动课程的 96%。干预后,组间体重无明显变化。与 UC 相比,HIIT 显著改善了总胆固醇(-0.40 mmol/L;95% 置信区间[CI],-0.70 至 -0.10;p = 0.011)、非高密度脂蛋白-c(-0.35 mmol/L;95% CI,-0.60 至 -0.11;p = 0.006)、胰岛素(-13.6 pmol/L;95% CI,-25.3 至 -1.8;p = 0.025)、胰岛素样生长因子(IGF)-1(-15.0 ng/mL;95% CI,-29.9 至 -0.1;p = 0.048)和 IGF 结合蛋白(IGFBP)-3(152.3 ng/mL;95% CI,12.6 至 292.1;p = 0.033)。空腹血糖、HbA1c、其他血脂指标、IGFBP-1、脂肪连素和瘦素均无明显差异:ERASE试验表明,为期12周的有氧HIIT计划改善了前列腺癌患者在AS治疗过程中的多种心脏代谢生物标志物,这可能有助于心血管健康,并可能影响前列腺癌进展的信号通路。还需要进一步的研究来证实运动对前列腺癌男性患者心血管代谢标志物的影响,并确定这些影响是否与长期临床结果的改善有关。
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来源期刊
Prostate Cancer and Prostatic Diseases
Prostate Cancer and Prostatic Diseases 医学-泌尿学与肾脏学
CiteScore
10.00
自引率
6.20%
发文量
142
审稿时长
6-12 weeks
期刊介绍: Prostate Cancer and Prostatic Diseases covers all aspects of prostatic diseases, in particular prostate cancer, the subject of intensive basic and clinical research world-wide. The journal also reports on exciting new developments being made in diagnosis, surgery, radiotherapy, drug discovery and medical management. Prostate Cancer and Prostatic Diseases is of interest to surgeons, oncologists and clinicians treating patients and to those involved in research into diseases of the prostate. The journal covers the three main areas - prostate cancer, male LUTS and prostatitis. Prostate Cancer and Prostatic Diseases publishes original research articles, reviews, topical comment and critical appraisals of scientific meetings and the latest books. The journal also contains a calendar of forthcoming scientific meetings. The Editors and a distinguished Editorial Board ensure that submitted articles receive fast and efficient attention and are refereed to the highest possible scientific standard. A fast track system is available for topical articles of particular significance.
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