Nodal T follicular helper cell lymphoma with aberrant CD20 expression and monoclonal TCR, IG rearrangements secondary to Classical Hodgkin Lymphoma: a case report.

IF 1.2 4区医学 Q3 PATHOLOGY

Medical Molecular Morphology Pub Date : 2024-12-01 Epub Date: 2024-07-16 DOI:10.1007/s00795-024-00398-9

Ning Zhu, Yu Pan, Liling Song, Na Li, Xiaolong Sui, Ping Yang, Xiaoqian Liu, Li Zhang, Guohua Yu

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Abstract

Classical Hodgkin Lymphoma (CHL) is a rare malignant neoplasm of the lymphatic system. While CHL typically responds well to conventional treatments, some cases may experience relapse to other subtypes, with the development of secondary peripheral T-cell lymphoma (PTCL) being relatively uncommon. Herein, we report a rare case of nodal T follicular helper cell lymphomas,nos (nTFHL-NOS) secondary to CHL, accompanied by aberrant CD20 expression and clonal rearrangements of T-cell receptor (TCR) and immunoglobulin (IG). A 74-year-old male, was diagnosed with CHL, leaning toward the mixed cell type, 6 years ago. He received six cycles of the Adriamycin, Bleomycin, Vinblastine, Dacarbazine (ABVD) regimen, achieving complete clinical remission. The patient was admitted to our hospital due to the appearance of multiple skin nodules 66 months later. Histopathological analysis revealed nTFHL-NOS, with aberrant CD20 expression and clonal rearrangements of TCR and IG. The patient underwent two cycles of chemotherapy with brentuximab vedotin and the Gemcitabine-Oxaliplatin (G-mox) regimen, resulting in a reduction of the skin lesions to 2 cm × 1 cm. We discuss this rare case and review related literature.

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结节性T滤泡辅助细胞淋巴瘤伴有CD20异常表达和单克隆TCR、IG重排，继发于典型霍奇金淋巴瘤：病例报告。

典型霍奇金淋巴瘤（CHL）是一种罕见的淋巴系统恶性肿瘤。虽然CHL通常对常规治疗反应良好，但有些病例可能会复发为其他亚型，而继发外周T细胞淋巴瘤（PTCL）则相对少见。在此，我们报告了一例继发于CHL的结节性T滤泡辅助细胞淋巴瘤（nTFHL-NOS）的罕见病例，该病例伴有CD20异常表达以及T细胞受体（TCR）和免疫球蛋白（IG）的克隆重排。一名 74 岁的男性患者 6 年前被诊断出患有混合细胞型 CHL。他接受了六个周期的阿霉素、博来霉素、长春新碱、达卡巴嗪（ABVD）治疗，临床症状完全缓解。66 个月后，患者因出现多发性皮肤结节而入院。组织病理学分析显示，患者患有 nTFHL-NOS，CD20 表达异常，TCR 和 IG 存在克隆性重排。患者接受了两个周期的布伦妥昔单抗维多汀和吉西他滨-奥沙利铂（G-mox）方案化疗，结果皮损缩小至 2 cm × 1 cm。我们将讨论这一罕见病例并回顾相关文献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Molecular Morphology 医学-病理学

CiteScore

2.90

自引率

5.60%

发文量

审稿时长

>12 weeks

期刊介绍： Medical Molecular Morphology is an international forum for researchers in both basic and clinical medicine to present and discuss new research on the structural mechanisms and the processes of health and disease at the molecular level. The structures of molecules, organelles, cells, tissues, and organs determine their normal function. Disease is thus best understood in terms of structural changes in these different levels of biological organization, especially in molecules and molecular interactions as well as the cellular localization of chemical components. Medical Molecular Morphology welcomes articles on basic or clinical research in the fields of cell biology, molecular biology, and medical, veterinary, and dental sciences using techniques for structural research such as electron microscopy, confocal laser scanning microscopy, enzyme histochemistry, immunohistochemistry, radioautography, X-ray microanalysis, and in situ hybridization. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.