Threshold effects between caffeine intake and urine flow rate: a population-based cross-sectional study.

IF 1.8 4区医学 Q3 UROLOGY & NEPHROLOGY

International Urology and Nephrology Pub Date : 2024-12-01 Epub Date: 2024-07-16 DOI:10.1007/s11255-024-04153-y

Yong Huang, Huiyi Su, Yingying Wang, Yao Zhang

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引用次数: 0

Abstract

Purpose: The potential benefits of caffeine intake are currently receiving much attention and exploration. Urine flow rate (UFR) is an objective index to comprehensively reflect bladder function. The aim of this study was to investigate the association between caffeine intake and UFR using the National Health and Nutrition Examination Survey (NHANES) database.

Methods: 14,142 participants were enrolled in this study. Weighted multivariate adjusted regression models were used to explore the relationship between caffeine intake and UFR. The dose-response relationships were explored using a restricted cubic spline (RCS) and a threshold effect analysis was conducted based on the inflection points identified by the two-segment linear regression model. In addition, subgroup analysis and sensitivity analysis were applied.

Results: The findings suggested that the intake of caffeine was correlated with improved UFR [Model 3: 0.091 (0.057, 0.126), P value < 0.001]. In addition, the RCS supported a nonlinear relationship between them. The analysis of threshold effect further revealed a specific level of caffeine intake (34.51 mg/day) that exhibited a significant enhancement in UFR. Finally, through re-analyzing the data set obtained after multiple imputation (MI), we obtained similar results.

Conclusion: This study found a nonlinear beneficial relationship between caffeine intake and UFR, and revealed the recommended intake of caffeine. The values varied by gender, race, education, and smoking status.

Abstract Image

查看原文本刊更多论文

咖啡因摄入量与尿流速率之间的阈值效应：一项基于人群的横断面研究。

目的：摄入咖啡因的潜在益处目前正受到广泛关注和探讨。尿流率（UFR）是全面反映膀胱功能的客观指标。本研究旨在利用美国国家健康与营养调查（NHANES）数据库调查咖啡因摄入量与尿流率之间的关系。采用加权多变量调整回归模型来探讨咖啡因摄入量与 UFR 之间的关系。使用受限立方样条线（RCS）探讨了剂量-反应关系，并根据两段线性回归模型确定的拐点进行了阈值效应分析。此外，还进行了亚组分析和敏感性分析：结果：研究结果表明，咖啡因的摄入量与 UFR 的改善相关[模型 3：0.091 (0.057, 0.126)，P 值结论：该研究发现咖啡因的摄入量与 UFR 的改善存在非线性相关性：本研究发现咖啡因摄入量与 UFR 之间存在非线性有益关系，并揭示了咖啡因的推荐摄入量。这些数值因性别、种族、教育程度和吸烟状况而异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Urology and Nephrology 医学-泌尿学与肾脏学

CiteScore

3.40

自引率

5.00%

发文量

329

审稿时长

1.7 months

期刊介绍： International Urology and Nephrology publishes original papers on a broad range of topics in urology, nephrology and andrology. The journal integrates papers originating from clinical practice.