Effectiveness of buccal administration of dexmedetomidine and ketamine combination in paediatric dental sedation: A randomized controlled clinical trial.

IF 2.3 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

International journal of paediatric dentistry Pub Date : 2024-07-16 DOI:10.1111/ipd.13238

Sara H El-Rouby, Yasmi O Crystal, Ahmed M Elshafie, Nadia A Wahba, Magda M El-Tekeya

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引用次数: 0

Abstract

Background: Pain and anxiety can be considerable obstacles while treating paediatric dental patients. Moderate sedation is needed to treat uncooperative patients.

Aim: This study aimed to compare the effectiveness of buccal administration of dexmedetomidine-ketamine combination versus dexmedetomidine.

Design: Fifty-six uncooperative children were randomly assigned into two groups: Group I received buccal dexmedetomidine (2 μg/kg) and ketamine (2 mg/kg) (DEX-KET), whereas Group II received buccal dexmedetomidine (4 μg/kg) (DEX). The effects of drugs were evaluated based on changes in vital signs, onset and duration of sedation, sedation level, analgesia, ease of treatment and procedural adverse effects.

Results: There were no significant differences in vital signs or sedation onset between the two groups. DEX-KET group showed shorter recovery time than DEX group (p < .0001). There were no statistically significant differences between both groups regarding sedation level at optimum sedation and during operative procedure (p = .064, p = .069 respectively). The ease of treatment was significantly better in DEX-KET group than in DEX group (p = .048). Procedural side effects and analgesic effects of the sedative drugs were comparable between both groups.

Conclusion: The combination of dexmedetomidine and ketamine delivered buccally provided a better method of delivering care to uncooperative children with more rapid recovery than dexmedetomidine.

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右美托咪定和氯胺酮联合口腔给药在儿童牙科镇静中的效果：随机对照临床试验。

背景：在治疗儿童牙科患者时，疼痛和焦虑可能是相当大的障碍。目的：本研究旨在比较右美托咪定-氯胺酮联合口腔给药与右美托咪定口腔给药的效果：设计：将 56 名不合作的儿童随机分为两组：第一组接受右美托咪定（2 μg/kg）和氯胺酮（2 mg/kg）口服液（DEX-KET），第二组接受右美托咪定（4 μg/kg）口服液（DEX）。根据生命体征的变化、镇静的开始和持续时间、镇静水平、镇痛、治疗的难易程度和手术不良反应来评估药物的效果：结果：两组患者的生命体征和镇静开始时间无明显差异。DEX-KET组比DEX组恢复时间短（P 结论：DEX-KET组比DEX组恢复时间短：与右美托咪定相比，右美托咪定和氯胺酮联合颊黏膜给药为不合作的儿童提供了更好的治疗方法，且恢复更快。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of paediatric dentistry 医学-小儿科

CiteScore

5.50

自引率

2.60%

发文量

审稿时长

6-12 weeks

期刊介绍： The International Journal of Paediatric Dentistry was formed in 1991 by the merger of the Journals of the International Association of Paediatric Dentistry and the British Society of Paediatric Dentistry and is published bi-monthly. It has true international scope and aims to promote the highest standard of education, practice and research in paediatric dentistry world-wide. International Journal of Paediatric Dentistry publishes papers on all aspects of paediatric dentistry including: growth and development, behaviour management, diagnosis, prevention, restorative treatment and issue relating to medically compromised children or those with disabilities. This peer-reviewed journal features scientific articles, reviews, case reports, clinical techniques, short communications and abstracts of current paediatric dental research. Analytical studies with a scientific novelty value are preferred to descriptive studies. Case reports illustrating unusual conditions and clinically relevant observations are acceptable but must be of sufficiently high quality to be considered for publication; particularly the illustrative material must be of the highest quality.