Effects of inactivity and exercise intervention on brain-derived neurotrophic factor in mice: Comparison of kinetics in serum, skeletal muscle, and brain.

IF 1.3 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Azusa Miki, Masahiro Aihara, Hikaru Kawaguchi, Noboru Hirose, Hiroki Hagiwara
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引用次数: 0

Abstract

Exercise training increases brain-derived neurotrophic factor (BDNF) expression and improves cognitive function. However, the dynamics of BDNF during inactivity and the effects of exercise intervention on BDNF levels have rarely been examined. Therefore, we aimed to examine changes in serum, skeletal muscle, and brain BDNF levels under these conditions. Mice were divided into control (Co), cast immobilization (CI), reloading (RL), and exercise (Ex) groups. Muscle atrophy was induced by cast immobilization for 2 weeks in the CI, RL, and Ex groups. After cast removal, the RL and Ex groups underwent regrounding and treadmill exercise, respectively, for 2 weeks. Serum, skeletal muscle, and brain BDNF levels showed a similar decreasing trend in the CI group, recovery in the RL group, and a further increase in the Ex group compared with those in the Co group. This indicates that BDNF levels change in parallel with the degree of activity. However, the magnitude of variation differed among the tissues in the order of serum > skeletal muscle > brain tissue. These results suggest that different mechanisms in different tissues regulate BDNF expression. BDNF could potentially act as an objective measure of the impact of both inactivity and exercise-based interventions.

不运动和运动干预对小鼠脑源性神经营养因子的影响:血清、骨骼肌和大脑中的动力学比较。
运动训练能增加脑源性神经营养因子(BDNF)的表达并改善认知功能。然而,人们很少研究不运动时 BDNF 的动态变化以及运动干预对 BDNF 水平的影响。因此,我们旨在研究在这些条件下血清、骨骼肌和大脑中 BDNF 水平的变化。小鼠被分为对照组(Co)、石膏固定组(CI)、重装组(RL)和运动组(Ex)。CI、RL和Ex组的小鼠通过石膏固定2周诱导肌肉萎缩。拆除石膏后,RL 组和 Ex 组分别进行为期 2 周的重磨和跑步机运动。与Co组相比,CI组的血清、骨骼肌和大脑BDNF水平呈相似的下降趋势,RL组有所恢复,Ex组进一步上升。这表明,BDNF 水平与活动程度呈平行变化。然而,不同组织的变化幅度不同,顺序为血清 > 骨骼肌 > 脑组织。这些结果表明,不同组织调节 BDNF 表达的机制不同。BDNF有可能成为衡量不运动和运动干预影响的客观指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomedical Research-tokyo
Biomedical Research-tokyo 医学-医学:研究与实验
CiteScore
2.40
自引率
0.00%
发文量
19
审稿时长
>12 weeks
期刊介绍: Biomedical Research is peer-reviewed International Research Journal . It was first launched in 1990 as a biannual English Journal and later became triannual. From 2008 it is published in Jan-Apr/ May-Aug/ Sep-Dec..
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