Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies.

IF 7 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Dmitry S Prudinnik, Aigul Kussanova, Ivan A Vorobjev, Alexander Tikhonov, Fazly I Ataullakhanov, Natasha S Barteneva
{"title":"Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies.","authors":"Dmitry S Prudinnik, Aigul Kussanova, Ivan A Vorobjev, Alexander Tikhonov, Fazly I Ataullakhanov, Natasha S Barteneva","doi":"10.14336/AD.2024.0526","DOIUrl":null,"url":null,"abstract":"<p><p>Aging is interrelated with changes in red blood cell parameters and functionality. In this article, we focus on red blood cells (RBCs) and provide a review of the known changes associated with the characterization of RBC deformability in aging and related pathologies. The biophysical parameters complement the commonly used biochemical parameters and may contribute to a better understanding of the aging process. The power of the deformability measurement approach is well established in clinical settings. Measuring RBCs' deformability has the advantage of relative simplicity, and it reflects the complex effects developing in erythrocytes during aging. However, aging and related pathological conditions also promote heterogeneity of RBC features and have a certain impact on the variance in erythrocyte cell properties. The possible applications of deformability as an early biophysical biomarker of pathological states are discussed, and modulating PIEZO1 as a therapeutic target is suggested. The changes in RBCs' shape can serve as a proxy for deformability evaluation, leveraging single-cell analysis with imaging flow cytometry and artificial intelligence algorithms. The characterization of biophysical parameters of RBCs is in progress in humans and will provide a better understanding of the complex dynamics of aging.</p>","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":null,"pages":null},"PeriodicalIF":7.0000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging and Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.14336/AD.2024.0526","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Aging is interrelated with changes in red blood cell parameters and functionality. In this article, we focus on red blood cells (RBCs) and provide a review of the known changes associated with the characterization of RBC deformability in aging and related pathologies. The biophysical parameters complement the commonly used biochemical parameters and may contribute to a better understanding of the aging process. The power of the deformability measurement approach is well established in clinical settings. Measuring RBCs' deformability has the advantage of relative simplicity, and it reflects the complex effects developing in erythrocytes during aging. However, aging and related pathological conditions also promote heterogeneity of RBC features and have a certain impact on the variance in erythrocyte cell properties. The possible applications of deformability as an early biophysical biomarker of pathological states are discussed, and modulating PIEZO1 as a therapeutic target is suggested. The changes in RBCs' shape can serve as a proxy for deformability evaluation, leveraging single-cell analysis with imaging flow cytometry and artificial intelligence algorithms. The characterization of biophysical parameters of RBCs is in progress in humans and will provide a better understanding of the complex dynamics of aging.

衰老和相关病症中异质红细胞的变形性。
衰老与红细胞参数和功能的变化息息相关。在本文中,我们将重点关注红细胞(RBC),并对衰老和相关病症中与红细胞变形性特征相关的已知变化进行综述。生物物理参数是对常用生化参数的补充,有助于更好地了解衰老过程。变形性测量方法的威力已在临床环境中得到证实。测量红细胞的变形性具有相对简单的优点,而且能反映红细胞在衰老过程中产生的复杂影响。然而,衰老和相关病理条件也会促进红细胞特征的异质性,并对红细胞特性的差异产生一定影响。本文讨论了将变形性作为病理状态的早期生物物理生物标志物的可能性,并提出了将 PIEZO1 作为治疗靶点的建议。利用成像流式细胞仪和人工智能算法进行单细胞分析,红细胞形状的变化可作为变形性评估的替代指标。目前正在对人类红细胞的生物物理参数进行表征,这将有助于更好地了解衰老的复杂动态。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Aging and Disease
Aging and Disease GERIATRICS & GERONTOLOGY-
CiteScore
14.60
自引率
2.70%
发文量
138
审稿时长
10 weeks
期刊介绍: Aging & Disease (A&D) is an open-access online journal dedicated to publishing groundbreaking research on the biology of aging, the pathophysiology of age-related diseases, and innovative therapies for conditions affecting the elderly. The scope encompasses various diseases such as Stroke, Alzheimer's disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes, and Hypertension. The journal welcomes studies involving animal models as well as human tissues or cells.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信