'From highs to lows: a cautionary tale of nitrous oxide recreational use leading to sub-acute combined degeneration of the cord'.

IF 0.5 Q3 MEDICINE, GENERAL & INTERNAL
Oxford Medical Case Reports Pub Date : 2024-07-13 eCollection Date: 2024-07-01 DOI:10.1093/omcr/omae068
Ayman Osman, Dalia Yousif, Simon Hickman, William Branagh
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引用次数: 0

Abstract

Background: Several causes lead to subacute combined degeneration (SACD) of the spinal cord, with nitrous oxide (N2O) inhalation rapidly emerging as the leading cause of functional Vitamin B12 deficiency [1].

Case presentation: A 28-year-old man presented with numbness in the extremities and an unstable gait despite having a normal serum Vitamin B12 level. He also disclosed the recreational abuse of N2O. Magnetic Resonance Imaging (MRI) of the cervical spine revealed abnormal signals consistent with SACD. The patient's condition gradually improved after treatment with high dose Vitamin B12. Given the increasing number of N2O-induced SACD cases, the potential for drug abuse requires vigilance from clinicians.

Conclusion: Healthcare providers are urged to inquire about a patient's history of N2O inhalation to prevent the missed diagnosis of SACD.

从高潮到低谷:一氧化二氮娱乐性使用导致脊髓亚急性联合变性的警示故事》。
背景:导致脊髓亚急性联合变性(SACD)的原因有多种,而吸入一氧化二氮(N2O)迅速成为功能性维生素 B12 缺乏症的主要原因[1]:一名 28 岁的男子因四肢麻木和步态不稳前来就诊,尽管他的血清维生素 B12 水平正常。他还透露曾在娱乐中滥用一氧化二氮。颈椎磁共振成像(MRI)显示出与 SACD 一致的异常信号。在接受大剂量维生素 B12 治疗后,患者的病情逐渐好转。鉴于N2O诱发SACD的病例越来越多,临床医生需要对药物滥用的可能性保持警惕:结论:医疗服务提供者应询问患者是否有吸入一氧化二氮的历史,以防止漏诊 SACD。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Oxford Medical Case Reports
Oxford Medical Case Reports MEDICINE, GENERAL & INTERNAL-
CiteScore
0.90
自引率
0.00%
发文量
125
审稿时长
19 weeks
期刊介绍: Oxford Medical Case Reports (OMCR) is an open access, peer-reviewed online journal publishing original and educationally valuable case reports that expand the field of medicine. The journal covers all medical specialities including cardiology, rheumatology, nephrology, oncology, neurology, and reproduction, comprising a comprehensive resource for physicians in all fields and at all stages of training. Oxford Medical Case Reports deposits all articles in PubMed Central (PMC). Physicians and researchers can find your work through PubMed , helping you reach the widest possible audience. The journal is also indexed in the Web of Science Core Collection . Oxford Medical Case Reports publishes case reports under the following categories: Allergy Audiovestibular medicine Cardiology and cardiovascular systems Critical care medicine Dermatology Emergency medicine Endocrinology and metabolism Gastroenterology and hepatology Geriatrics and gerontology Haematology Immunology Infectious diseases and tropical medicine Medical disorders in pregnancy Medical ophthalmology Nephrology Neurology Oncology Paediatrics Pain Palliative medicine Pharmacology and pharmacy Psychiatry Radiology, nuclear medicine, and medical imaging Respiratory disorders Rheumatology Sexual and reproductive health Sports Medicine Substance abuse.
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