Inpatient mortality and outcomes of COVID-19 among patients with non-ischemic cardiomyopathy: A propensity matched analysis.

IF 2.4 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart & Lung Pub Date : 2024-11-01 Epub Date: 2024-07-15 DOI:10.1016/j.hrtlng.2024.06.018

Mirza Faris Ali Baig, Kalyan Chaliki

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引用次数: 0

Abstract

Background: Patients with chronic medical conditions, particularly cardiovascular diseases, are at a greater risk of adverse outcomes due to COVID-19. The effect of COVID-19 on patients with non-ischemic cardiomyopathy (NICM) is not known well.

Objectives: To study the impact of COVID-19 infection on NICM hospital mortality and other outcomes.

Methods: This study included a cohort of patients from the 2020 and 2021 National Inpatient Sample databases. Patients hospitalized for COVID-19 with and without NICM were matched using a 1:1 propensity score-matching ratio. Outcomes analyzed were in-hospital mortality, rates of acute kidney injury (AKI), acute myocardial infarction (AMI), cardiogenic shock, cardiac arrest, mechanical ventilation, tracheal intubation, pulmonary embolism (PE), ventricular tachycardia (VT), ventricular fibrillation (VF), length of stay (LOS), and total hospitalization charges.

Results: A total of 2,532,652 patients met the inclusion criteria (1,199,008 females [47.3 %], predominantly white 1,456,203 (57.5 %); mean [SD] age 63 [5.4] years), including 64,155 (2.5 %) patients with a history of NICM. Following propensity matching, 10,258 COVID-19 patients with and without NICM were matched. Patients with NICM had higher rates of AMI (11.1 vs. 7.1 %, p < 0.001), cardiogenic shock (2 vs. 0.6 %, p < 0.001), cardiac arrest (4.4 vs. 3.2 %, p < 0.01), mechanical ventilation (13.7 vs 12 %, p < 0.01), VT (8.5 vs. 2.2 %, p < 0.001), and VF (1.0 vs 0.25 %, p < 0.001). The odds ratios for in-hospital mortality, AKI, and PE did not differ significantly.

Conclusion: A History of NICM does not affect COVID-19 mortality but increases the risk of cardiovascular complications.

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非缺血性心肌病患者的住院死亡率和 COVID-19 的疗效：倾向匹配分析

背景：患有慢性疾病，尤其是心血管疾病的患者因 COVID-19 而出现不良后果的风险更大。COVID-19对非缺血性心肌病（NICM）患者的影响尚不清楚：研究 COVID-19 感染对非缺血性心肌病（NICM）住院死亡率和其他结果的影响：本研究纳入了 2020 年和 2021 年全国住院患者抽样数据库中的一组患者。因感染 COVID-19 而住院的患者与未感染 NICM 的患者按 1:1 的倾向得分匹配比例进行匹配。分析的结果包括院内死亡率、急性肾损伤（AKI）、急性心肌梗死（AMI）、心源性休克、心脏骤停、机械通气、气管插管、肺栓塞（PE）、室性心动过速（VT）、心室颤动（VF）、住院时间（LOS）和住院总费用：共有 2,532,652 名患者符合纳入标准（1,199,008 名女性[47.3%]，1,456,203 名白人（57.5%）；平均 [SD] 年龄 63 [5.4] 岁），其中包括 64,155 名（2.5%）有 NICM 病史的患者。经过倾向匹配后，10258 名 COVID-19 患者中有和没有 NICM。NICM 患者发生急性心肌梗死（11.1% 对 7.1%，P＜0.001）、心源性休克（2% 对 0.6%，P＜0.001）、心脏骤停（4.4% 对 3.2%，P＜0.01）、机械通气（13.7% 对 12%，P＜0.01）、VT（8.5% 对 2.2%，P＜0.001）和室颤（1.0% 对 0.25%，P＜0.001）的比例较高。院内死亡率、AKI 和 PE 的几率没有显著差异：结论：NICM病史不会影响COVID-19死亡率，但会增加心血管并发症的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heart & Lung 医学-呼吸系统

CiteScore

4.60

自引率

3.60%

发文量

184

审稿时长

35 days

期刊介绍： Heart & Lung: The Journal of Cardiopulmonary and Acute Care, the official publication of The American Association of Heart Failure Nurses, presents original, peer-reviewed articles on techniques, advances, investigations, and observations related to the care of patients with acute and critical illness and patients with chronic cardiac or pulmonary disorders. The Journal''s acute care articles focus on the care of hospitalized patients, including those in the critical and acute care settings. Because most patients who are hospitalized in acute and critical care settings have chronic conditions, we are also interested in the chronically critically ill, the care of patients with chronic cardiopulmonary disorders, their rehabilitation, and disease prevention. The Journal''s heart failure articles focus on all aspects of the care of patients with this condition. Manuscripts that are relevant to populations across the human lifespan are welcome.