Interrelationship between thyroid hormones and reduced renal function, a review article.

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM
Sadaf Agahi, Atieh Amouzegar, Mohammadjavad Honarvar, Fereidoun Azizi, Ladan Mehran
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引用次数: 0

Abstract

Background: Understanding the relationship of thyroid hormones with the development of chronic kidney disease (CKD) has important clinical implications for managing patients with both thyroid and kidney dysfunction. In this review, our purpose was to provide a thorough comprehension of the interplay between thyroid hormones, thyroid dysfunctions, and CKD. While there is evidence linking thyroid hormone levels to renal diseases, the association between thyroid hormones, specifically within the normal range, and the risk of CKD incidence is still a subject of debate. The Google Scholar, PubMed, Scopus, and Web of Science, were searched using the medical subject heading (MeSH) terms for the relevant keywords up to December 2023.

Conclusion: Based on the review, the development of CKD is more consistently associated with higher serum TSH and thereafter lower serum free T3 levels; however, its association with free T4 is more controversial. Furthermore, subclinical and overt hypothyroidisms were considerably associated with incident CKD. Hyperthyroidism and Hashimoto thyroiditis might increase the risk of CKD.

甲状腺激素与肾功能减退之间的相互关系,综述文章。
背景:了解甲状腺激素与慢性肾脏病(CKD)发病的关系对于管理同时患有甲状腺和肾功能异常的患者具有重要的临床意义。在这篇综述中,我们的目的是全面了解甲状腺激素、甲状腺功能障碍和慢性肾脏病之间的相互作用。尽管有证据表明甲状腺激素水平与肾脏疾病有关,但甲状腺激素(尤其是正常范围内的甲状腺激素)与慢性肾功能衰竭发病风险之间的关系仍存在争议。我们使用医学主题词表(MeSH)对谷歌学术、PubMed、Scopus 和 Web of Science 进行了检索,相关关键词的检索期截至 2023 年 12 月:根据综述,慢性肾功能衰竭的发生与血清促甲状腺激素(TSH)升高和血清游离 T3 水平降低的关系较为一致;但与游离 T4 的关系却存在较大争议。此外,亚临床和显性甲状腺功能减退症与慢性肾功能衰竭的发生有很大关系。甲状腺功能亢进症和桥本氏甲状腺炎可能会增加罹患慢性肾脏病的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Thyroid Research
Thyroid Research Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
3.10
自引率
4.50%
发文量
21
审稿时长
8 weeks
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